The role of immune cells in the etiology of endometriosis

• Project/Area Number: 21791543
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: KOUGA Kawori 東京大学, 医学部附属病院, 助教 (10396723)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 子宮内膜症 / 免疫 / 樹状細胞 / 腹腔内環境 / 免疫担当細胞 / T細胞 / 好中球

Research Abstract

DCs phagocyte endometrial cell in retrograde menstruation and provoke inflammation and in turn contribute to the progress endometriosis.

Research Products

• [Journal Article] Proteinase-activated receptors in the endometrium and endometriosis (2012)
  • Author(s): Osuga Y, Hirota Y, Yoshino O, Hirata T, Koga K, Taketani Y.
  • Journal Title: Front Biosci (Schol Ed) Volume: 1;4 Pages: 1201-12
  • Peer Reviewed
• [Journal Article] Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma (2011)
  • Author(s): Yoshino O, Izumi G, Shi J, Osuga Y, Hirota Y, Hirata T, Harada M, Nishii O, Koga K, Taketani Y.
  • Journal Title: Fertil Steril Volume: 96(1) Pages: 118-21
  • Peer Reviewed
• [Journal Article] Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis (2011)
  • Author(s): Hirata T, Osuga Y, Takamura M, Saito A, Hasegawa A, Koga K, Yoshino O, Hirota Y, Harada M, Taketani Y.
  • Journal Title: Fertil Steril Volume: 96(1) Pages: 113-7
  • Peer Reviewed
• [Journal Article] TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 (2011)
  • Author(s): Saito A, Osuga Y, Yoshino O, Takamura M, Hirata T, Hirota Y, Koga K, Harada M, Takemura Y, Yano T, Taketani Y.
  • Journal Title: Hum Reprod Volume: 26(7) Pages: 1892-8
  • Peer Reviewed
• [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis: a pilot study (2011)
  • Author(s): Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Gynecol Endocrinol Volume: 27(9) Pages: 717-20
  • Peer Reviewed
• [Journal Article] Lymphocytes in endometriosis (2011)
  • Author(s): Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y.
  • Journal Title: Am J Reprod Immunol Volume: 65(1) Issue: 1 Pages: 1-10
  • DOI: 10.1111/j.1600-0897.2010.00887.x
  • Peer Reviewed
• [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells. (2010)
  • Author(s): Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano T, Taketani Y.
  • Journal Title: Endocrinology Volume: 151(11) Pages: 5468-76
  • Peer Reviewed
• [Journal Article] Successful management of a ruptured endometrial cyst in acute leukemia (2010)
  • Author(s): Taguchi A, Koga K, Osuga Y, Fujimoto A, Miyasaka A, Yano T, Kurokawa M, Taketani Y.
  • Journal Title: Fertil Steril Volume: 95(1)
  • Peer Reviewed
• [Journal Article] Autoamputated adnexa presents as a peritoneal loose body (2010)
  • Author(s): Koga K, Hiroi H, Osuga Y, Nagai M, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 93 Pages: 967-968
  • Peer Reviewed
• [Journal Article] Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders (2010)
  • Author(s): Koga K, Mor G
  • Journal Title: Am J Reprod Immunol Volume: 63 Pages: 587-600
  • Peer Reviewed
• [Journal Article] Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole (2010)
  • Author(s): Koga K, Osuga Y, Tajima T, Hirota Y, Igarashi T, Fujii T, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 94 Pages: 305-308
  • Peer Reviewed
• [Journal Article] Phagocytosis of apoptotic trophoblast cells by human endometrial endothelial cells induces proinflammatory cytokine production (2010)
  • Author(s): Peng B, Koga K, Cardenas I, Aldo P, Mor G
  • Journal Title: Am J Reprod Immunol Volume: 64 Pages: 12-19
  • Peer Reviewed
• [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells (2010)
  • Author(s): Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano T, Taketani Y
  • Journal Title: Endocrinology Volume: 151 Pages: 5468-5476
  • Peer Reviewed
• [Journal Article] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells (2010)
  • Author(s): Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirata T, Takemura Y, Yano T, Taketani Y
  • Journal Title: Hum Reprod Volume: 25 Pages: 751-756
  • Peer Reviewed
• [Journal Article] Interleukin-4 induces expression of eotaxin in endometriotic stromat cells (2010)
  • Author(s): Ouyang Z, Osuga Y, Hirota Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 94 Pages: 58-62
  • Peer Reviewed
• [Journal Article] Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole. (2010)
  • Author(s): Koga K, Osuga Y, Tajima T, Hirota Y, Igarashi T, Fujii T, Yano T, Taketani Y.
  • Journal Title: Fertil Steril. Volume: 94 Pages: 305-8
  • Peer Reviewed
• [Journal Article] Interleukin-4 induces expression of eotaxin in endometriotic stromal cells. (2010)
  • Author(s): Ouyang Z, Osuga Y, Hirota Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y.
  • Journal Title: Fertil Steril Volume: 94 Pages: 58-62
  • Peer Reviewed
• [Journal Article] Autoamputated adnexa presents as a peritoneal loose body. (2010)
  • Author(s): Koga K, Hiroi H, Osuga Y, Nagai M, Yano T, Taketani Y.
  • Journal Title: Fertil Steril. Volume: 93 Pages: 967-8
  • Peer Reviewed
• [Journal Article] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. (2010)
  • Author(s): Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirata T, Takemura Y, Yano T, Taketani Y.
  • Journal Title: Hum Reprod. Volume: 25 Pages: 751-6
  • Peer Reviewed
• [Journal Article] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision (2009)
  • Author(s): Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y.
  • Journal Title: Hum Reprod Volume: 24(12) Pages: 3042-8
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells. (2009)
  • Author(s): Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y.
  • Journal Title: Fertil Steril. Volume: 92 Pages: 1794-8
  • Peer Reviewed
• [Journal Article] Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision. (2009)
  • Author(s): Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y.
  • Journal Title: Hum Reprod. Volume: 24 Pages: 3042-8
  • Peer Reviewed
• [Remarks]
  • URL: http://plaza.umin.ac.jp/emsis/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/emsis/