The Role of Maternal Aging in the Fetal Programming Hypothesis
| Project/Area Number |
21791550
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
UMEKAWA Takashi Mie University, 医学部附属病院, 助教 (80422864)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 母体生活環境 / 食生活の欧米化 / 高脂肪食 / 胎児プログラミング / DOHaD / 高血圧 / 糖脂質代謝異常 / 酸化ストレス / Developmental Origins of Health and Disease (DOHaD) / 妊娠 / 耐糖能異常 / thioredoxin / Pancreas duodenum homeobox-1 / 肥満 / インスリン抵抗性 |
|---|
| Research Abstract |
In order to clarify the role of maternal excess fat intake in the fetal programming, we investigated the effects of a maternal high-fat diet before and during pregnancy on blood pressure and glucose and lipid metabolism in offspring. As a result, a maternal high-fat diet before and during pregnancy predisposes their offspring to hypertension and to the disturbance of glucose and lipid metabolism in adult life.
|
Report
(3 results)
Research Products
(43 results)
