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Identification of microRNA which regulates peritoneal dissemination of ovarian cancer

Research Project

Project/Area Number 21791555
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

SAWADA Kenjiro  Osaka University, 医学部附属病院, 助教 (00452392)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsマイクロRNA / 腹膜播種 / 卵巣癌 / インテグリン / 播種 / インテグリンa5
Research Abstract

Ovarian cancer is a highly metastatic characterized by widespread peritoneal dissemination and ascites, and is the leading cause of death from gynecological malignancy. We have previously identified integrinα5 as a new target in ovarian cancer treatment by inhibiting peritoneal dissemination. Our aim is to identify new microRNA which regulates the expression of integrinα5 and analyze the therapeutic potential of targeting of its microRNA. Based on the microRNA algorism search, we identified hsa-mir-92a as a candidate. Hsa-mir-92a is little expressed in ovarian cancer cells which express high level of integrinα5, whereas hsa-mir-92a is highly expressed in RMUG-S cells which do not express integrinα5. Transfection of precursor mir-92a reduced integrinα5 expression in ovarian cancer cells, accompanied by the inhibition of cell adhesion and invasion. Those results suggested targeting hsa-mir-92a could be a promising therapy for a subset of ovarian cancer patients by inhibiting integrin α5 expression.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis.2011

    • Author(s)
      Mitra AK, Sawada K, Tiwari P, Mui K, Gwin K, Lengyel E.
    • Journal Title

      Oncogene 30(13)

      Pages: 1566-76

    • Related Report
      2010 Final Research Report
  • [Journal Article] CD95 promotes tumour growth.2010

    • Author(s)
      Chen L, Park SM, Tumanov AV, Hau A, Sawada K., et al.
    • Journal Title

      Nature

      Volume: 465 Pages: 492-496

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.2009

    • Author(s)
      Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige K, Kimura T.
    • Journal Title

      Endocrinology 150(9)

      Pages: 4306-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.2009

    • Author(s)
      Ogata S, Morishige K, Sawada K, et al.
    • Journal Title

      Int J Gynecol Cancer 19

      Pages: 1473-1480

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and itskey role in the migration of extravillous trophoblast cells during early implantation.2009

    • Author(s)
      Arimoto-Ishida E, Sakata M, Sawada K, et al.
    • Journal Title

      Endocrinology 150

      Pages: 4306-4315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of microRNA which regulates peritoneal dissemination of ovarian cancer2010

    • Author(s)
      Ohyagi, C.Sawada, K.Mabuchi, S.Kimura, T.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of microRNA which regulates peritoneal dissemination of ovarian cancer.2010

    • Author(s)
      Ohyagi C, Sawada K, Mabuchi S, Kimura T.
    • Organizer
      In:第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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