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Effect of inhibition targeting TS gene for chemotherapy sensitivity in head and neck adenoid cystic carcinoma

Research Project

Project/Area Number 21791586
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionHirosaki University

Principal Investigator

SHIRASAKI Takashi  Hirosaki University, 大学院・医学研究科, 客員研究員 (20419980)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsTS遺伝子 / 頭頸部癌 / 抗癌剤 / 腺様嚢胞癌 / TS遺伝 / siRNA / 5-FU
Research Abstract

Adenoid cystic carcinoma(ACC) is resistant to 5-FU treatment. We investigated whether reductive expression of the TS gene improves chemo-sensitivity for 5-FU,it as well as the in vivo effect of TS inhibition. Results showed that TS gene inhibition did not improve chemo-sensitivity while it was effective in in vivo experiments.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 2008 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma2008

    • Author(s)
      Takashi Shirasaki, Shin-ichiro Maruya, Hiroki Mizukami, Seiji Kakehata, Hidekachi Kurotaki, Soroku Yagihashi, Hideichi Shinkawa
    • Journal Title

      BMC Cancer 8

      Pages: 348-348

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] siRNAを用いたTS knock down の唾液腺腺様嚢胞癌への影響2010

    • Author(s)
      白崎隆
    • Organizer
      第151回日耳鼻青森県地方部会
    • Place of Presentation
      青森県
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] siRNAを用いたTS knock downの唾液腺腺様嚢胞癌細胞への影響2009

    • Author(s)
      白崎隆
    • Organizer
      第110回日本耳鼻咽喉科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] siRNAを用いたTS knock down の唾液腺腺様嚢胞癌への影響2009

    • Author(s)
      白崎隆
    • Organizer
      第110回日本耳鼻咽喉科学会
    • Place of Presentation
      東京都
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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