Study of the middle ear reconstruction with bone morphogenetic protein
| Project/Area Number |
21791594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
SUGIMOTO Akira 千葉大学, 大学院・医学研究院, 助教 (50436432)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 側頭骨再生 / 骨形成蛋白(BMP) / マイクロCT / 鼓室形成術 / 乳突削開術 / 含気化 / 多血小板由来成長因子(PDGF) / βリン酸三カルシウム(β-TCP) / 骨再生 / 中耳再建 / 耳毒性 |
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| Research Abstract |
There is currently no established method for reconstructing temporal bone defects after tympanoplasty or mastoidectomy. Bone tissue reconstruction using tissue engineering techniques is currently receiving attention. This study demonstrated that micro CT devices for animals are very effective for observing bone regeneration. Moreover, of the bone morphogenetic proteins that are capable of forming normal bone, BMP-2 was more efficient at bone formation than PDGF and β-TCP. BMP-2 was shown to have a strong ability to reconstruct bone tissue in temporal bone, and construction of a pneumatic space was confirmed for the first time.
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Report
(4 results)
Research Products
(18 results)
