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Association of neck metastasis with tongue cancer stem cells.

Research Project

Project/Area Number 21791603
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

KONDO Satoru  金沢大学, 附属病院, 助教 (70436822)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords舌がん / 癌幹細胞 / 頸部リンパ節転移 / 分化 / スフェロイド
Research Abstract

Using side population method and spheroid cultivating method, we have sorted cancer stem like cell(CSC) and non-CSC from tongue cancer cell line, OSC19. We transplanted the CSC and non-CSC to tongue of nude mouse and determined frequency of neck metastasis. CSC formed more tumor of tongue and neck metastasis than non-CSC. However, non-CSC could form neck metastasis by increasing of cell the number of cells transplanted. Upon with these findings, we concluded that both CSC and non-CSC have phenotype of cancer stem cells. By analysis with immuno-histochemistry with tongue cancer tissues, CD44 and ABCG2 were determined as candidates of CSC-metastatic marker although the expression does not relate with worse prognosis. Suppression of phenotypes of CSC may control neck metastasis of tongue cancer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (6 results)

  • [Journal Article] Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma2012

    • Author(s)
      Wakisaka N, Hirota K, Kondo S, Sawada-Kitamura S, Endo K, Murono S, Yoshizaki T
    • Journal Title

      Oral Oncol

      Volume: 48(8) Issue: 8 Pages: 703-8

    • DOI

      10.1016/j.oraloncology.2012.02.003

    • NAID

      120003959476

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of garenoxacin in the treatment of upper respiratory tract infections2012

    • Author(s)
      Ito M, Maruyama Y, Murono S, Wakisaka N, Kondo S, Hatano M, Nakanishi S, Miwa T, Yoshizaki T
    • Journal Title

      AurisNasus Larynx

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of garenoxacin in the treatment of upperrespiratory tract infections.2012

    • Author(s)
      Ito M, Maruyama Y, Murono S, Wakisaka N, Kondo S, Hatano M, Nakanishi S, MiwaT, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 39(5) Issue: 5 Pages: 512-8

    • DOI

      10.1016/j.anl.2011.09.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus latent membrane protein 1 inducescancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines2011

    • Author(s)
      Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, YamaokaS, Pagano JS, Yoshizaki T
    • Journal Title

      Jvirol

      Volume: 85(21) Issue: 21 Pages: 11255-64

    • DOI

      10.1128/jvi.00188-11

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus latent membrane protein 1 induces Snail andepithelial-mesenchymal transition inmetastatic nasopharyngeal carcinoma2011

    • Author(s)
      Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, Pagano JS
    • Journal Title

      Br J Cancer

      Volume: 104 Issue: 7 Pages: 1160-1167

    • DOI

      10.1038/bjc.2011.38

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of epithelial-mesenchymal transition in squamous cell carcinoma of the temporal bone2011

    • Author(s)
      Sugimoto H, Ito M, Hatano M, Kondo S, Suzuki S, Yoshizaki T
    • Journal Title

      Otol Neurotol

      Volume: 32 Issue: 3 Pages: 483-7

    • DOI

      10.1097/mao.0b013e31820d9654

    • NAID

      120002986040

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pseudoaneurysm of the lingual artery after concurrent intra-arterial chemotherapy with radiotherapy for advanced tongue cancer.2011

    • Author(s)
      Murono S, Nakanishi Y, Inoue D, Ozaki K, Kondo S, Wakisaka N, Matsui O,Yoshizaki T
    • Journal Title

      Head Neck

      Volume: 33(8) Issue: 8 Pages: 1230-2

    • DOI

      10.1002/hed.21372

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma.2011

    • Author(s)
      Horikawa T, Yoshizaki T, Kondo S, et al.
    • Journal Title

      Br J Cancer

      Volume: 104 Pages: 1160-1167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pseudoaneurysm of the lingual artery after concurrent intra-arterial chemotherapy with radiotherapy for advanced tongue cancer.2010

    • Author(s)
      Murono S, Kondo S, Wakisaka N, et al.
    • Journal Title

      Head Neck

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An extremely rare case of large Delphian node metastasis preceding primary laryngeal cancer.2009

    • Author(s)
      Murono S, Hirota K, Kondo S, Wakisaka N, Furukawa M, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 36(5) Issue: 5 Pages: 614-7

    • DOI

      10.1016/j.anl.2009.01.010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration2009

    • Author(s)
      Endo K, Kondo S, Shackleford J, Horikawa T, Kitagawa N, Yoshizaki T, Furukawa M, Zen Y, Pagano JS
    • Journal Title

      Oncogene

      Volume: 28 Issue: 14 Pages: 1725-35

    • DOI

      10.1038/onc.2009.20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings.2009

    • Author(s)
      Wakisaka N, Kondo S, Murono S, Minato H, Furukawa M, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 36(3) Issue: 3 Pages: 367-71

    • DOI

      10.1016/j.anl.2008.05.010

    • NAID

      120001342300

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration.2009

    • Author(s)
      Endo K, Kondo S, Furukawa M, et al.
    • Journal Title

      Oncogene 28

      Pages: 1725-1735

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings2009

    • Author(s)
      Wakisaka N, Kondo S, Furukawa M, et al.
    • Journal Title

      Auris Nasus Larynx 36

      Pages: 367-371

    • NAID

      120001130408

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent intra-arterial chemotherapy and radiotherapy for advanced 1 aryngeal cancer.2009

    • Author(s)
      Yoshizaki T, Kondo S, et al.
    • Journal Title

      Ann Otol Rhinol Laryngol. 118

      Pages: 172-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Epstein Barr Virus Latent Membrane Protein 1 Initiates Cancer Progenitor Cells in Epithelial Cell Lines2011

    • Author(s)
      近藤悟
    • Organizer
      第59回日本ウィルス学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Epstein Barr Virus Latent Membrane Protein 1 Initiates Cancer Progenitor Cells in Epithelial Cell Lines2011

    • Author(s)
      近藤悟
    • Organizer
      第59回日本ウィルス学会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] EBVにより上咽頭癌幹細胞は誘導されるか?-第二報-2011

    • Author(s)
      近藤悟、中西庸介、遠藤一平、脇坂尚宏、室野重之、吉崎智一
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウィンクあいち(愛知)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] EBVにより上咽頭癌幹細胞は誘導されるか?-第二報-2011

    • Author(s)
      近藤悟、中西庸介, ら
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウィンクあいち(名古屋市)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epstein BarrウィルスLMP1による上皮系細胞における癌前駆細胞形質の誘導2010

    • Author(s)
      近藤悟、脇坂尚宏、遠藤一平、室野重之、古川仭、吉崎智一
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 進行口腔癌に対する浅側頭動脈経由持続動注化学療法2009

    • Author(s)
      近藤悟、室野重之、古川仭、吉崎智一
    • Organizer
      第33回頭頸部癌学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2009-06-12
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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