Exploration of the generator of tinnitus using magnetencephalography

• Project/Area Number: 21791612
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: HIRAUMI Harukazu Kyoto University, 医学研究科, 助教 (10374167)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 耳鳴 / 脳磁場計測 / ガンマ帯域 / スペクトラム解析 / 空間フィルター

Research Abstract

The spectral analysis of the auditory evoked magnetic fields revealed alpha synchronization and beta de-synchronization in auditory cortex. Spontaneous gamma band activity was measured in unilateral tinnitus patients. In all patients, the gamma band activity around the auditory cortex showed predominance in the non-tinnitus side. This asymmetry diminished after the administration of masking noise.

Research Products

• [Journal Article] Multivariate analysis of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Journal Title: Acta Otolaryngol Suppl. 563 Pages: 24-28
  • Peer Reviewed
• [Journal Article] Cochlear implantation in patients with prelingual hearing loss. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Journal Title: Acta Otolaryngol Suppl. 563 Pages: 4-10
  • Peer Reviewed
• [Journal Article] Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss : a prospective clinical trial. (2010)
  • Author(s): Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, Ono K, Yamamoto M, Tabata Y, Teramukai S, Tanaka S, Tada H, Onodera R, Yonezawa A, Inui K, Ito J
  • Journal Title: BMC Med. 25;8:76
  • NAID: 120002661525
  • Peer Reviewed
• [Journal Article] 人工内耳の問題点と対応 (2010)
  • Author(s): 平海晴一、山口忍、伊藤壽一
  • Journal Title: 音声言語医学 51:2 Pages: 203-206
  • NAID: 10026252208
• [Journal Article] Multivariate analysis of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Journal Title: Acta Otolaryngol Volume: 130 Pages: 24-28
  • Peer Reviewed
• [Journal Article] Cochlear implantation in patients with prelingual hearing loss. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Journal Title: Acta Otolaryngol Volume: 130 Pages: 4-10
  • Peer Reviewed
• [Journal Article] 人工内耳の問題点と対応 (2010)
  • Author(s): 平海晴一、山口忍、伊藤壽一
  • Journal Title: 音声言語医学 Volume: 51 Pages: 203-206
  • NAID: 10026252208
• [Journal Article] Abnormal auditory cortex with giant N100m signal in patients with autosomal dominant lateral temporal lobe epilepsy. (2009)
  • Author(s): Usui K, Ikeda A, Nagamine T, Matsubayashi J, Matsumoto R, Hiraumi H, Kawamata J, Matsuhashi M, Takahashi R, Fukuyama H.
  • Journal Title: Clin Neurophysiol. 120 Pages: 1923-1926
  • Peer Reviewed
• [Journal Article] Lobulated petrous apex cholesterol granuloma treated with infracochlear and transsphenoidal approaches. (2009)
  • Author(s): Hiraumi H, Nakagawa T, Kanemaru S, Ito J
  • Journal Title: Int Adv Otol. 5 Pages: 404-407
  • Peer Reviewed
• [Journal Article] Lobulated petrous apex cholesterol granuloma treated with infracochlear and transsphenoidal approaches (2009)
  • Author(s): Hiraumi H, Nakagawa T, Ito J
  • Journal Title: Int Adv Otol. 5 Pages: 404-407
  • Peer Reviewed
• [Journal Article] Abnormal auditory cortex with giant N100m signal in patients with autosomal dominant lateral temporal lobe epilepsy. (2009)
  • Author(s): Usui K, Ikeda A, Nagamine T, Matsubayashi J, Matsumoto R, Hiraumi H, Kawamata J, Matsuhashi M, Takahashi R, Fukuyama H
  • Journal Title: Clin Neurophysiol 120 Pages: 1923-1926
  • Peer Reviewed
• [Presentation] Minimally Invasive Approach for Cochlear Implantation Using a Microendoscope. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: Kyoto
• [Presentation] Temporal bone chondroblastoma totally invisible on MRI. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: 13th Korea Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul
• [Presentation] 言語習得前失聴者における人工内耳 (2010)
  • Author(s): 平海晴一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第72回耳鼻咽喉科臨床学会
  • Place of Presentation: 倉敷市
• [Presentation] The effect of pre-operative developmental delay on speech intelligibility of children with cochlear implant. (2010)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: Joint Meeting-Vth EAONO Instructional Workshop / IVth Consensus in Auditory Implants
  • Place of Presentation: Parma
• [Presentation] 人工内耳ピンホールサージェリーの試み (2010)
  • Author(s): 平海晴一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第111回日本耳鼻咽喉科・頭頸部外科学会学術講演会
  • Place of Presentation: 仙台市
• [Presentation] The effect of pre-operative developmental delay on speech intelligibility of children with cochlear implant (2010)
  • Author(s): Harukazu Hiraumi, Norio Yamamoto, Tatsunori Sakamoto, Juichi Ito
  • Organizer: Joint Meeting-Vth EAONO Instructional Workshop/IVth Consensus in Auditory Implants
  • Place of Presentation: Parma, Italy
• [Presentation] Minimally Invasive Approach for Cochlear Implantation Using a Microendoscope (2010)
  • Author(s): Harukazu Hiraumi, Norio Yamamoto, Tatsunori Sakamoto, Juichi Ito
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: Kyoto
• [Presentation] 人工内耳 ピンホールサージェリーの試み (2010)
  • Author(s): 平海晴一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第111回日本耳鼻咽喉科・頭頸部外科学会学術講演会
  • Place of Presentation: 仙台市
• [Presentation] Cochlear implantation in deaf children with additional disabilities. (2009)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: 7th Asia Pacific Symposium on Cochlear Implants and Related Sciences
  • Place of Presentation: Singapore
• [Presentation] 重複障害のある難聴児への聴覚言語獲得支援.人工内耳の問題点と対応 (2009)
  • Author(s): 平海晴一
  • Organizer: 第54回日本音声言語医学会総会・学術講演会
  • Place of Presentation: 福島市
• [Presentation] 人工内耳埋め込み術後耳に対する再手術症例の検討 (2009)
  • Author(s): 平海晴一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第19回日本耳科学会総会・学術講演会
  • Place of Presentation: 東京都
• [Presentation] Revision in Cochlear Implant Surgery. (2009)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: 27th Politzer Society Meeting
  • Place of Presentation: London
• [Presentation] 経乳突手術時に大錐体神経を明瞭に確認できた1例 (2009)
  • Author(s): 平海晴一、三浦誠、金丸眞一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第71回耳鼻咽喉科臨床学会
  • Place of Presentation: 旭川市
• [Presentation] 蜂巣発育不良耳での経迷路法による聴神経腫瘍摘出 (2009)
  • Author(s): 平海晴一、金丸眞一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第110回日本耳鼻咽喉科・頭頸部外科学会学術講演会
  • Place of Presentation: 東京都
• [Presentation] Histopathology of the soft tissues preserved in the cholesteatoma surgery. (2009)
  • Author(s): Hiraumi H, Kanemaru S, Miura M, Yamamoto N, Sakamoto T, Ito J
  • Organizer: The 6th Extraordinary International Symposium on Recent Advances in Otitis Media
  • Place of Presentation: Seoul
• [Presentation] Revision in Cochlear Implant Surgery. (2009)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: 27th Politzer Society Meeting
  • Place of Presentation: Queen Elizabeth II England conference center (London)
• [Presentation] 人工内耳埋め込み術後耳に対する再手術症例の検討 (2009)
  • Author(s): 平海晴一、山本典生、坂本達則、伊藤壽一
  • Organizer: 第19回日本耳科学会総会・学術講演会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 重複障害のある難聴児への聴覚言語獲得支援.人工内耳の問題点と対応 (2009)
  • Author(s): 平海晴一
  • Organizer: 第54回日本音声言語医学会総会・学術講演会
  • Place of Presentation: コラッセふくしま(福島市)
• [Presentation] Cochlear implantation in deaf children with additional disabilities (2009)
  • Author(s): Hiraumi H, Yamamoto N, Sakamoto T, Ito J
  • Organizer: 7th Asia Pacific Symposium on Cochlear Implants and Related Sciences
  • Place of Presentation: Raffles City Convention Centre (SIngapore)