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Clinical studies, immunological analysis, and antigen structure analysis about Alloiococcus otitidis

Research Project

Project/Area Number 21791627
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTokai University (2010)
Sapporo Medical University (2009)

Principal Investigator

HARIMAYA Atsushi  Tokai University, 医学部, 講師 (90448605)

Research Collaborator FUJII Nobuhiro  札幌医科大学, 医学部, 教授
YOKOTA Shin-Ichi  札幌医科大学, 医学部, 准教授
IIDA Masahiro  東海大学, 医学部, 教授
HIMI Tetsuo  札幌医科大学, 医学部, 教授
MONTEIRO Mario A.  カナダ・ゲルフ大学, 教授
ALAR Sharif  カナダ・ゲルフ大学
YAMAGUCHI Hiroyuki  北海道大学, 保健科学研究院, 教授
YLIKOSKI Jukka  フィンランド・ヘルシンキ大学
MATTILA Petri  フィンランド・ヘルシンキ大学
TARKKANEN Jussi  フィンランド・ヘルシンキ大学
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords耳科学 / 中耳炎 / アロイオコッカス
Research Abstract

Optimal growth condition of Alloiococcus otitidis was analyzed and the frequency of this organism was investigated. In addition, host immune response against Alloiococcus otitidis was investigated and the antigen structure of the organism was analyzed.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2010

    • Author(s)
      Kamekura, et al.
    • Journal Title

      Cell Tissue Res (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis.2009

    • Author(s)
      Harimaya A, Fujii N, Himi T.
    • Journal Title

      Int J Pediatr Otorhinolaryngol 73

      Pages: 677-680

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2009

    • Author(s)
      Kamekura R, Kojima T, Koizumi JI, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N.
    • Journal Title

      Cell Tissue Res 338

      Pages: 283-293

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis.2009

    • Author(s)
      Harimaya, et al.
    • Journal Title

      Int J Pediatr Otorhinolaryngol 73

      Pages: 677-680

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of anaerobic and oligotrophic conditions on survival of Alloiococcus otitidis, implicated as a cause of otitis media.

    • Author(s)
      Matsuo J, Harimaya A, Fukumoto T, Nakamura S, Yoshida M, Takahashi K, Iida M, Fujii N, Yamaguchi H.
    • Journal Title

      J Infect Chemother 印刷中

    • NAID

      10029523562

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of anaerobic and oligotrophic conditions on survival of Alloiococcus otitidis, implicated as a cause of otitis media.

    • Author(s)
      Matsuo,Harimaya, et al.
    • Journal Title

      J Infect Chemother

      Volume: (in press)

    • NAID

      10029523562

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児中耳炎の新種細菌に関する話題について2010

    • Author(s)
      播摩谷敦
    • Organizer
      川崎市耳鼻咽喉科医会
    • Place of Presentation
      川崎市
    • Year and Date
      2010-12-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 新種中耳起炎菌アロイオコッカスの至適発育条件に関する検討2010

    • Author(s)
      播摩谷敦
    • Organizer
      感染症治療フォーラム
    • Place of Presentation
      伊勢原市
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 反復性中耳炎小児におけるアデノイド切除前後の鼻咽腔細菌叢の動態について2010

    • Author(s)
      播摩谷敦、新谷朋子、濱田昌史、小田桐恭子、関口美也子、塚原桃子、飯田政弘
    • Organizer
      日本耳鼻咽喉科学会神奈川県地方部会
    • Place of Presentation
      横浜
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 新種細菌アロイオコッカスの中耳炎における臨床的意義について2010

    • Author(s)
      播摩谷敦
    • Organizer
      第73回相武耳鼻科研究会
    • Place of Presentation
      厚木市
    • Year and Date
      2010-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Alloiococcus otitidis induces interleukin-8 via NF-kappaB, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 pathways in human cells.2010

    • Author(s)
      Harimaya A, Fujii N, Himi T, Iida M.
    • Organizer
      13th Korea-Japan Joint Meeting of Otorhinolaryngology=Head and Neck Surgery.
    • Place of Presentation
      Seoul, Korea.
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児中耳炎の新たな原因菌と考えられるAlloiococcus otitidisの生存性を規定する要因に関する基礎的な検討2010

    • Author(s)
      福元達也、播摩谷敦、松尾淳司、秋沢宏次、清水力、飯田政弘、藤井暢弘、山口博之
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児中耳炎の新たな原因菌と考えられるAlloiococcus otitidisの生存性2010

    • Author(s)
      福元達也、播摩谷敦、松尾淳司、鈴木春樹、清水力、松野一彦、飯田政弘、藤井暢弘、山口博之
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 中耳炎好発児におけるアデノイド手術前後の鼻咽腔細菌叢動態に関する検討2010

    • Author(s)
      播摩谷敦、新谷朋子、氷見徹夫、濱田昌史、小田桐恭子、関口美也子、塚原桃子、飯田政弘
    • Organizer
      第20回日本耳科学会総会・学術講演会
    • Place of Presentation
      松山市
    • Related Report
      2010 Final Research Report
  • [Presentation] Alloiococcus otitidis induoes interleukin-8 via NF-kappaB, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase1/2 pathways in human cells.2010

    • Author(s)
      Harimaya, et al.
    • Organizer
      13th Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新種細菌Alloiococcus otitidis菌体成分に対する抗体の検出、ならびに多糖体抗原の構造解析。2009

    • Author(s)
      播摩谷敦, ら
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新種細菌アロイオコッカスの中耳炎における臨床的意義について2009

    • Author(s)
      播摩谷敦
    • Organizer
      URIEM
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 新種細菌Alloiococcus otitidis菌体成分に対する抗体の検出、ならびに多糖体抗原の構造解析2009

    • Author(s)
      播摩谷敦、Mario A Monteiro、横田伸一、氷見徹夫、藤井暢弘
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Novel polysaccharide immunogens from Alloiococcus otitidis and synthesis of a glycoconjugate vaccine thereof.2009

    • Inventor(s)
      Montero MA, Arar S, Harimaya A
    • Industrial Property Rights Holder
      Montero MA, Arar S, Harimaya A
    • Acquisition Date
      2009-03-19
    • Related Report
      2010 Final Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2025-11-18  

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