Grant-in-Aid for Young Scientists (B)
This study was conducted to establish the full-thickness defect model of rabbit esophagus and to examine usability of PGA(polyglycolic acid) sheet to regenerate of rabbit esophagus. One week after the operation, a connective tissue layer formed under the PGA sheet. Two weeks after models showed the extension of the mucosal layer along that connective tissue. It was found that PGA sheet disappeared until four weeks after surgery. The smooth muscle layer regenerated in disarray in contrast to the mucosal layer reconstructing continuously. All models that treated more than 12mm horizontal defect of esophagus died. It was considered that durability of PGA sheet was not enough to regenerate in broad defect.
Attribution of KAKENHI