| Project/Area Number |
21791653
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
MORI Atsuko Osaka Medical College, 医学部, 助教 (40368105)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 内耳電気生理 / 蝸牛内直流電位 / 蝸牛管抵抗 / 細胞内カルシウム / 低酸素負荷 / 耳科学 / イオンチャネル / 辺縁細胞 / 無呼吸負荷 / 利尿剤 / L型Ca^<2+>チャネル / TRPCチャネル |
|---|
| Research Abstract |
We measured the changes in EP and cochlear partition resistance (CoPR) induced by asphyxia. The CoPR was decreased after the perfusion with control artificial endolymph, and was increased after the asphyxia. The perfusion with artificial endolymph containing BAY K8644 decreased both the CoPR and the EP, and the CoPR was increased by the asphyxia. These results suggest that increase in the CoPR induced by the asphyxia might not be mediated by the elevation of cytosolic Ca^<2+> in the cochlear cells.
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