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Cure development of anticancer agent sensitivity and the cancer stem cell in head and neck cancer

Research Project

Project/Area Number 21791660
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research Institution愛知県がんセンター (2011)
Nagoya University (2009-2010)

Principal Investigator

SUZUKI Hidenori  愛知県がんセンター, 研究所・腫瘍病理学部, 研究員 (70470169)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords頭頸部外科学 / FDG-PET / FDG-PET/CT / 頭頸部癌 / 抗癌剤感受性 / 癌幹細胞 / 治療抵抗性 / 抗がん剤感受性 / 頭頚部癌 / Sox2 / 抗癌剤感受性試験
Research Abstract

In oral squmous cell carcinoma, SUVmax was related with tumor thickness and depth of invasion. Tumors with SUVmax ≧12 showed shorter 3-year overall survival, greater tumor thickness and depth of invasion, and higher average Bcl-2 intensity. SUVmax is non-invasive and useful parameter for predicting patients’ prognosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas2009

    • Author(s)
      Suzuki H, Fukuyama R, Hasegawa Y, Tamaki T, Nishio M, Nakashima T, Tatematsu M.
    • Journal Title

      Oral Oncol.

      Volume: 45(10)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas2009

    • Author(s)
      Hidenori Suzuki
    • Journal Title

      Oral Oncology 45

      Pages: 891-897

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of osteopontin and CDX2: indications of phenotypes and prognosis in advanced gastric cancer

    • Author(s)
      Zhang X, Tsukamoto T, Mizoshita T, Ban H, Suzuki H, ToyodaT, Tatematsu M.
    • Journal Title

      Oncol Rep.

      Volume: 21(3)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 喉頭癌と下咽頭癌における切除病理所見と術前情報の検討2011

    • Author(s)
      鈴木秀典
    • Organizer
      第63回日本気管食道科学学会
    • Place of Presentation
      名古屋東急ホテル(名古屋)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] FDG UPTAKE PREDICTS IN PATIENTS WITH HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA2011

    • Author(s)
      鈴木秀典
    • Organizer
      1^<st> Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2011-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] FDG UPTAKE PREDICTS SURVIVAL IN PATIENTS WITH HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA2011

    • Author(s)
      鈴木秀典
    • Organizer
      1^<st> Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2011-07-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下咽頭癌におけるFDG-PETによる予後予測についての検討2011

    • Author(s)
      鈴木秀典
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウィンク愛知(名古屋)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 下咽頭癌におけるFDG-PETによる予後予測についての検討2011

    • Author(s)
      鈴木秀典
    • Organizer
      第35回日本頭頚部癌学会
    • Place of Presentation
      ウインク愛知(名古屋)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下咽頭癌におけるFDG集積2011

    • Author(s)
      鈴木秀典
    • Organizer
      第28回東海頭頸部腫瘍研究会
    • Place of Presentation
      ウィンク愛知(名古屋)
    • Year and Date
      2011-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 下咽頭癌におけるFDG集積2011

    • Author(s)
      鈴木秀典
    • Organizer
      第28回東海頭頸部腫瘍研究会
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前腸発生に深く関与する転写因子Sox2の頭頸部癌における意義2009

    • Author(s)
      鈴木秀典
    • Organizer
      第61回日本気管食道科学総会
    • Place of Presentation
      横浜ベイシェラトン(神奈川)
    • Year and Date
      2009-11-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 前腸発生に深く関与する転写因子Sox2の頭頸部癌における意義2009

    • Author(s)
      鈴木秀典
    • Organizer
      第61回 日本気管食道科学会総会
    • Place of Presentation
      横浜ベイシェラトン(神奈川)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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