EFFECT OF CALPAINS ON PHOTORECEPTOR DEGENERATION AND POSSIBILITY OF NEW TREATMENT FOR PHOTORECEPTOR PROTECTION
| Project/Area Number |
21791662
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hirosaki University |
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Principal Investigator |
METOKI Tomomi Hirosaki University, 医学部附属病院, 講師 (00400169)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜色素変性 / カルパイン / 視細胞 / アポトーシス / ミトコンドリア / 細胞質 / アポトーシス誘導因子 / RCSラット |
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| Research Abstract |
We studied in this project whether and how calpains, calcium activated proteases, play roles in the photoreceptor apoptosis during retinal degeneration of retinitis pigmentosa model animals. We found that activities of mitochondrial calpains increased in the early stage of retinal degeneration of Royal College Surgeon's (RCS) rats. We also found that intravitreal injection of calpain inhibitors specifically retarded photoreceptor apoptosis.
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Report
(3 results)
Research Products
(23 results)
