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EFFECT OF CALPAINS ON PHOTORECEPTOR DEGENERATION AND POSSIBILITY OF NEW TREATMENT FOR PHOTORECEPTOR PROTECTION

Research Project

Project/Area Number 21791662
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionHirosaki University

Principal Investigator

METOKI Tomomi  Hirosaki University, 医学部附属病院, 講師 (00400169)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords網膜色素変性 / カルパイン / 視細胞 / アポトーシス / ミトコンドリア / 細胞質 / アポトーシス誘導因子 / RCSラット
Research Abstract

We studied in this project whether and how calpains, calcium activated proteases, play roles in the photoreceptor apoptosis during retinal degeneration of retinitis pigmentosa model animals. We found that activities of mitochondrial calpains increased in the early stage of retinal degeneration of Royal College Surgeon's (RCS) rats. We also found that intravitreal injection of calpain inhibitors specifically retarded photoreceptor apoptosis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Effect of nilvadipine on central visual field in retinitis pigmentosa : a 30-month clinical trial.2011

    • Author(s)
      Nakazawa M, Ohguro H, Takeuchi K, Miyagawa Y, Ito T, Metoki T.
    • Journal Title

      Ophthalmologica 225(1)

      Pages: 120-126

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of nilvadipine on central visual field in retinitis pigmentosa : a 30-month clinical trial.2011

    • Author(s)
      Nakazawa M, Ohguro H, Takeuchi K, Miyagawa Y, Ito T, Metoki T
    • Journal Title

      Ophthalmologica

      Volume: 225 Pages: 120-126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Solid Hyaluronic Acid Film on Postoperative Fibrous Scar Formation after Strabismus Surgery in Animals2010

    • Author(s)
      Takeuchi K, Nakazawa M, Metoki T, Yamazaki H, Miyagawa Y, Ito T.
    • Journal Title

      J Pediat Ophth Strab. In press.

    • Related Report
      2010 Final Research Report
  • [Journal Article] Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.2010

    • Author(s)
      Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, Ishiguro S.
    • Journal Title

      Exp Eye Res. 91

      Pages: 353-361

    • Related Report
      2010 Final Research Report
  • [Journal Article] Morphological findings of intraocular lens with haptics detached from optics following cataract surgery.2010

    • Author(s)
      Suzuki Y, Suzuki K, Metoki T, Nakazawa M.
    • Journal Title

      Ophthalmic Surgery, Lasers & Imaging in press.

    • Related Report
      2010 Final Research Report
  • [Journal Article] トラボプロスト点眼液の点状表層角膜症に対する影響2010

    • Author(s)
      山崎仁志、宮川靖博、目時友美、鈴木香、伊藤忠、横井由美子、木村智美、中澤満
    • Journal Title

      あたらしい眼科 27(8)

      Pages: 1123-1126

    • NAID

      10027747814

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of Solid Hyaluronic Acid Film on Postoperative Fibrous Scar Formation after Strabismus Surgery in Animals2010

    • Author(s)
      Takeuchi K, Nakazawa M, Metoki T, Yamazaki H, Miyagawa Y, Ito T
    • Journal Title

      J Pediat Ophth Strab.

      Volume: (印刷中 (web上で公開))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.2010

    • Author(s)
      Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, Ishiguro S
    • Journal Title

      Experimental Eye Research

      Volume: 91 Pages: 353-361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 各種緑内障手術の成績2009

    • Author(s)
      木村智美、石川太、山崎仁志、目時友美、伊藤忠、竹内侯雄、中澤満
    • Journal Title

      あたらしい眼科 26(9)

      Pages: 1279-1285

    • NAID

      10026256368

    • Related Report
      2010 Final Research Report
  • [Journal Article] Solid hyaluronic acid prevents postoperative fibrous scar formation in experimental animal eyes.2009

    • Author(s)
      Takeuchi K, Nakazawa M, Yamazaki H, Miyagawa Y, Ito T, Ishikawa F, Metoki T.
    • Journal Title

      Arch Ophthalmol 127(4)

      Pages: 460-464

    • Related Report
      2010 Final Research Report
  • [Journal Article] 内境界膜自然剥離を伴った黄斑円孔症例2009

    • Author(s)
      伊藤忠、山崎仁志、横井由美子、目時友美、竹内侯雄、木村智美、中澤満、楠美智己
    • Journal Title

      あたらしい眼科 26(12)

      Pages: 1693-1696

    • NAID

      10026923740

    • Related Report
      2010 Final Research Report
  • [Journal Article] 各種緑内障手術の成績2009

    • Author(s)
      木村智美、目時友美, 他
    • Journal Title

      あたらしい眼科 26

      Pages: 1279-1285

    • NAID

      10026256368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid hyaluronic acid prevents postoperative fibrous scar formation in experimental animal eyes2009

    • Author(s)
      Takeuchi K, Metoki T, et al.
    • Journal Title

      Archives of Ophthalmology 127

      Pages: 460-464

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内境界膜自然剥離を伴った黄斑円孔症例2009

    • Author(s)
      伊藤忠、目時友美, 他
    • Journal Title

      あたらしい眼科 26

      Pages: 1693-1696

    • NAID

      10026923740

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥厚性硬膜炎と眼窩先端症候群を呈した症例2011

    • Author(s)
      目時友美、鈴木幸彦、木村智美、盛泰子、横井由美子、竹内侯雄、鈴木香、伊藤忠、宮川靖博、中澤満、野田康子
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2011-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性の中心視野進行への影響2010

    • Author(s)
      中澤満、大黒浩、山崎仁志、目時友美、宮川靖博、伊藤忠、竹内侯雄、横井由美子
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性の中心視野進行への影響2010

    • Author(s)
      中澤満、目時友美, (ほか)
    • Organizer
      第64回 日本臨床眼科学会総会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 両眼の再発性視神経炎を初発症状とした抗好中球細胞質抗体関連腎炎2010

    • Author(s)
      鈴木香、鈴木幸彦、伊藤忠、目時友美、中澤満
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 眼内悪性リンパ腫を契機に発見されたT細胞リンパ腫の1例2010

    • Author(s)
      横井由美子、山崎仁志、目時友美、鈴木幸彦、木村智美、鈴木香、伊藤忠、中澤満、高畑武功、和田龍一、杉田直
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性に対する進行遅延効果2009

    • Author(s)
      中澤満、大黒浩、山崎仁志、目時友美、宮川靖博、伊藤忠、竹内侯雄、横井由美子
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] トレハロースによる結膜および皮膚線維芽細胞の抑制効果について2009

    • Author(s)
      竹内侯雄、蝦名祐一、山崎仁志、宮川靖博、伊藤忠、目時友美、横井由美子、中澤満
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] RCSラット網膜変性に対するミトコンドリアカルパインの関与とその制御の時間効果2009

    • Author(s)
      中澤満、目時友美, 他
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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