EFFECT OF ISOPROPYLUNOPROSTONE ON PHOTORECEPTOR PROTECTION
| Project/Area Number |
21791663
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hirosaki University |
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Principal Investigator |
ITO Tadashi Hirosaki University, 大学院・医学研究科, 助教 (00431453)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜色素変性 / イソプロピルウノプロストン / 視細胞 / アポトーシス / 視細胞保護 / RCSラット / ロドプシン |
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| Research Abstract |
Topical application of isopropyl unoprostone retarded progression of retinal degeneration in the rhodopsin transgenic rats (P23H). Degeneration of rod photoreceptor outer segments were apparently protected in the treated rats comparing to the control rats by electron microscopic investigation. On the other hand, there was no difference in gene expressions in the retina between both groups by DNA microarray analysis. These results indicated that protective effects of topical unoprostone may not be a direct effect to photoreceptors.
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Report
(3 results)
Research Products
(24 results)
