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The regulatory phenotype in human PE-induced Treg cells

Research Project

Project/Area Number 21791672
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

HORIE Shintarou  Tokyo Medical and Dental University, 医学部附属病院, 医員 (40376744)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords眼炎症 / 制御性T細胞 / 細胞治療 / 眼色素上皮細胞 / 活性化T細胞抑制 / ヒト細胞
Research Abstract

Murine retinal pigment epithelial (RPE) cells suppress T-cell activation by releasing soluble inhibitory factors and promote the generation of regulatory T cells in vitro. In the present study, we showed that human RPE-induced Treg cells are also able to acquire regulatory function when human RPE cell lines were pretreated with recombinant TGFb2. These RPE-induced Treg cells produced immune suppressive cytokines, and they significantly suppressed the activation of target cell lines and intraocular T-cell clones. Moreover, CD4^+CD25^+RPE-induced Treg cells expressed CTLA-4 and Foxp3 molecules, and the CD25^+Treg cells profoundly suppressed the T-cell activation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Human retinal pigment epithelium-inducded CD4+CD25+regulatory T cells suppress activation of intraocular effector T cells.2010

    • Author(s)
      Horie S, Sugita S, et al.
    • Journal Title

      Clinical Immunology vol.136(1)

      Pages: 83-95

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of B-Cell Activation by Retinal Pigment Epithelium.2010

    • Author(s)
      Sugita S, Horie S, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci vol.51(11)

      Pages: 5783-5788

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals.2010

    • Author(s)
      Sugita S, Horie S, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci vol.51(5)

      Pages: 2529-2536

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta.2010

    • Author(s)
      Yamada Y, Sugita S, Horie S, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci vol.51(5)

      Pages: 2548-2557

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human retinal pigment epithelium-inducded CD4+CD25+regulatory T cells suppress activation of intraocular effector T cells2010

    • Author(s)
      Horie S, et al
    • Journal Title

      Clinical Immunology

      Volume: 136 Pages: 83-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals2010

    • Author(s)
      Sugita S, Horie S, et al
    • Journal Title

      Investigative Opthalmology and Visual Sciences

      Volume: 51 Pages: 2529-2536

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of B-cell activation by retinal pigment epithelium2010

    • Author(s)
      Sugita S, Horie S, et al
    • Journal Title

      Investigative Opthalmology and Visual Sciences

      Volume: 51 Pages: 5783-5788

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction.2009

    • Author(s)
      Horie S, Sugita S, et al.
    • Journal Title

      Exp Eye Res vol.88(6)

      Pages: 1033-1042

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.2009

    • Author(s)
      Sugita S, Horie S, et al.
    • Journal Title

      J Immunol vol.183(8)

      Pages: 5013-5022

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human iris pigment epithelium suppress activation of bystandar T cells via TGF beta-TGF beta receptor interaction2009

    • Author(s)
      Horie S, et al.
    • Journal Title

      Experimental Eye Research 88

      Pages: 1033-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iris pigment epithelium-inducing regulatory T cells suppress bystander T helper1 cells via negative costimulatory signals2009

    • Author(s)
      Sugita S, Horie S, et al.
    • Journal Title

      Investigative Opthalmology and Visual Sciences (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye derived CTLA-2 alpha during inflammatory conditions2009

    • Author(s)
      Sugita S, Horie S, et al.
    • Journal Title

      Journal of Immunology 183

      Pages: 5013-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Potential Effects of Toll-Like Receptor 4 Signaling on RPE Dedifferentiation by TGFb.2010

    • Author(s)
      Horie S, et al.
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale (Fl, USA)
    • Year and Date
      2010-05-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Potential Effects of Toll-Like Receptor 4 Signaling on RPE Dedifferentiation by TGFb2010

    • Author(s)
      Horie S, et al
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale (Fl, USA)
    • Year and Date
      2010-05-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Human retinal pigment epithelium-induced CD4^+CD25^+ regulatory T cells suppress activation of intraocular effector T cells.2009

    • Author(s)
      Horie S, et al.
    • Organizer
      10th International Ocular Inflammation Society.
    • Place of Presentation
      Prague (Czech)
    • Year and Date
      2009-05-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Human retinal pigment epithelium-induced CD4^+CD25^+ regulatory T cells suppress activation of intraocular effector T cells2009

    • Author(s)
      Horie S, et al.
    • Organizer
      10th International Ocular Inflammation Society
    • Place of Presentation
      Prague(Czech)
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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