Development of neuroprotective therapy for glaucoma with anti-Alzheimer' s agent using rat model
| Project/Area Number |
21791682
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
MIKI Atsuya 大阪大学, 医学系・研究科, 助教 (30437404)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 眼細胞生物学 / 緑内障 / 神経保護 / 動物モデル / アルツハイマー病 |
|---|
| Research Abstract |
By ligation of rat episcleral veins, elevation of intraocular pressure(IOP) from 13. 2mmHg preoperatively to 19. 4mmHg at 5 weeks after operation after ligation of 2 veins, and from 14. 6mmHg to 20. 7 mmHg after ligation of 3 veins, was observed. By cauterizing rat episcleral veins, mean IOP was 10. 3 mmHg preoperatively, and 10. 0 mmHg at 1 week after operation. We did not observe any significant change in IOP after anterior chamber angle photocoagulation or after intravitreal injection of steroids.
|
Report
(4 results)
Research Products
(24 results)
