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The regulation of the expression of membrane-associated mucins in the ocular surface

Research Project

Project/Area Number 21791683
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionToho University

Principal Investigator

HORI Yuichi  東邦大学, 医学部, 准教授 (70379171)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsドライアイ / ムチン / オキュラーサーフェス / 膜型ムチン / MUC16 / 塩化ベンザルコニウム / 薬剤毒性角膜症 / ローズベンガル / 角膜上皮 / 結膜膜皮 / MUC1 / MUC4 / コンタクトレンズ
Research Abstract

The Ocular Surface Epithelia express membrane-associated mucins, MUC1, MUC4, and MUC16, which play an important role of the ocular surface barrier function. In our study, we reported that contact lens solutions(MPSs : Multi Purpose Solutions) containing boric acid significantly reduced gene expressions of MUC1, MUC4 and MUC16mRNA in the human corneal epithelial cells. Among ingredients, 0.1% boric acid significantly reduced gene expressions of MUC1and MUC16.Furthermore, we observed that preservative agent of eye drop, benzalkonium chloride(BAC), reduced the expression of MUC16mRNA and damaged the mucin barrier function in the human conjunctival epithelial cells. We believe that our results can help us to figure out the mechanism of the drug-induced keratopathy and to develop the useful eye drops with fewer side effects.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (20 results) Book (7 results)

  • [Journal Article] ドライアイとムチンの関係2012

    • Author(s)
      堀裕一
    • Journal Title

      あたらしい眼科

      Volume: 29 Pages: 323-339

    • URL

      http://www.atagan.jp/article/20120307.htm

    • Related Report
      2011 Final Research Report
  • [Journal Article] ドライアイとムチンとの関連2012

    • Author(s)
      堀裕一
    • Journal Title

      あたらしい眼科

      Volume: 29 Pages: 323-239

    • NAID

      10030547032

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Assessment of effects of multipurpose contact lens care solutions on human corneal epithelial cells2011

    • Author(s)
      Tchedre KT, Imayasu M, Hori Y, Cavanagh HD
    • Journal Title

      Eye & Contact Lens

      Volume: 37 Issue: 5 Pages: 328-330

    • DOI

      10.1097/icl.0b013e31822c36c2

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3次元前眼部光干渉断層計を用いた乱視矯正角膜切開術2011

    • Author(s)
      堀裕一, 出口雄三, 吉田いづみ, 芦澤純也, 日谷光一郎, 柴友明, 西信良嗣, 前野貴俊
    • Journal Title

      眼科手術

      Volume: 24(1) Pages: 87-90

    • NAID

      10031162659

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 治療用としてシリコーンハイドロゲルを装用中にムチンボールの出現を認めた2症例2011

    • Author(s)
      吉田いづみ, 堀裕一, 金井秀仁, 出口雄三, 芦澤純也, 日谷光一郎, 柴友明, 西信良嗣, 前野貴俊, 佐野研二
    • Journal Title

      眼科臨床紀要

      Volume: 4(2) Pages: 125-128

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of multipurpose contact lens solutions their ingredients on membrane-associated mucins of human corneal epithelial cells2010

    • Author(s)
      Imayasu M, Hori Y, Cavanagh HD
    • Journal Title

      Eye & Contact Lens

      Volume: 36(6) Issue: 6 Pages: 95-99

    • DOI

      10.1097/icl.0b013e3181faa43e

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyhexamethylene Biguanide(PHMB)を含有するハードコンタクトレンズ用洗浄保存液の抗菌効果2010

    • Author(s)
      堀裕一、前田直之、井上智之、坂本雅子
    • Journal Title

      日本コンタクトレンズ学会誌

      Volume: 52(2) Pages: 95-99

    • URL

      http://www.agm-net.com/contact/src/pdf.php?id=1209

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal Intermittent Serious Hypoxia and Reoxygenation in Proliferative Diabetic Retinopathy Cases2010

    • Author(s)
      Shiba T, Maeno T, Saishin Y, Hori Y, Takahashi M
    • Journal Title

      American Journal of Ophthalmology

      Volume: 149(6) Pages: 959-963

    • URL

      http://dx.doi.org/10.1016/j.ajo.2010.01.006

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of multipurpose contact lens solutions their ingredients on membrane-associated mucins of human corneal epithelial cells.2010

    • Author(s)
      Imayasu M, Hori Y, Cavanagh HD
    • Journal Title

      Eye & Contact Lens.

      Volume: 36(6) Pages: 361-366

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal Intermittent Serious Hypoxia and Reoxygenation in Prolifer ative Diabetic Retinopathy Cases2010

    • Author(s)
      Shiba T, Maeno T, Saishin Y, Hori Y, Takahashi M
    • Journal Title

      American Journal of Ophthalmology

      Volume: 149(6) Pages: 959-963

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 涙点プラグの使い分け2010

    • Author(s)
      堀裕一
    • Journal Title

      日本の眼科

      Volume: 81(4) Pages: 491-492

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 強膜炎の外科的治療2010

    • Author(s)
      堀裕一
    • Journal Title

      眼科

      Volume: 52(9) Pages: 1177-1182

    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩化ベンザルコニウム非含有緑内障点眼の眼表面膜型ムチン発現の影響2011

    • Author(s)
      堀裕一
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 塩化ベンザルコニウム非含有緑内障点眼の眼表面膜型ムチン発現の影響2011

    • Author(s)
      堀裕一
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] valuation of MUC16 Expression Induced by Benzalkonium Chloride on the Ocular Surface Epithelium2011

    • Author(s)
      Hori Y, Deguchi Y, Ashizawa J, Hitani K, Shiba T, Saishin Y, Maeno T
    • Organizer
      ARVO2011
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2011-05-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Multipurpose Contact Lens Care Solutions On Membrane-Associated Mucins Expressions In the Rat Cornea2011

    • Author(s)
      KT.Tchedre
    • Organizer
      ARVO 2011
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2011-05-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of MUC16 Expression Induced by Benzalkonium Chloride on the Ocular Surface Epithelium2011

    • Author(s)
      Y Hori
    • Organizer
      ARVO 2011
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2011-05-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ドライアイに関する最近の話題~眼表面におけるムチン発現とその役割について~2011

    • Author(s)
      堀裕一
    • Organizer
      第328回岩手県眼科集談会(招待講演)
    • Place of Presentation
      盛岡
    • Year and Date
      2011-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ドライアイに関する最近の話題~眼表面におけるムチン発現とその役割について~2011

    • Author(s)
      堀裕一
    • Organizer
      第328回岩手県眼科集談会
    • Place of Presentation
      盛岡グラントホテル(岩手県)(招待講演)
    • Year and Date
      2011-04-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Multi-Purpose Solutions and Their Ingredients on Membrane-Associated Mucins of Human Corneal Epithelial Cells2010

    • Author(s)
      Masaki Imayasu, Yuichi Hori, Kissaou Tchedre, H Dwight Cavanagh
    • Organizer
      The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      ウェスティン都ホテル京都(京都府)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Antibacterial Efficacy of Contact Lens Solutions Containing Polyhexamethylene Biguanide(PHMB) for Rigid Gas Permeable Lenses2010

    • Author(s)
      Hori Y
    • Organizer
      2010CLAO ERF Scientific Symposium
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] The Antibacterial Efficacy of Contact Lens Solutions Containing Polyhexamethylene Biguanide (PHMB) for Rigid Gas Permeable Lenses.2010

    • Author(s)
      Yuichi Hori
    • Organizer
      2010 CLAO ERF Scientific Symposium
    • Place of Presentation
      Caesars Palace Las Vegas Hotel (USA)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 治療用使用のシリコーンハイドロゲルレンズにおけるムチンボールの出現について2010

    • Author(s)
      吉田いづみ、堀裕一、出口雄三、芦澤純也、日谷光一郎、柴友明、西信良嗣、前野貴俊、佐野研二
    • Organizer
      第53回日本コンタクトレンズ学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウムBUT短縮のメカニズムに迫る「ムチンから見る」2010

    • Author(s)
      堀裕一
    • Organizer
      第4回箱根ドライアイクラブ
    • Place of Presentation
      兵庫
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウムBUT短縮のメカニズムに迫る「ムチンから見る」2010

    • Author(s)
      堀裕一
    • Organizer
      第4回箱根ドライアイクラブ
    • Place of Presentation
      ウェスティンホテル淡路(兵庫県)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of Multi-Purpose Contact-Lens Care Solusions and Their Ingredients on Membrane-Associated Mucins at the Corneal Epithelial Cells.2010

    • Author(s)
      M.Imayasu, Y.Hori, H.D.Cavanagh
    • Organizer
      ARVO2010
    • Place of Presentation
      Broward County Convention Center (USA)
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparison of Central Corneal Thickness, Anterior Chamber Depth, and Central Corneal Power Measurements between Two Scheimpflug Imaging Systems2010

    • Author(s)
      Hori Y and Deguchi Y
    • Organizer
      2010ASCRS Symposium & Congress
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of Central Corneal Thickness, Anterior Chamber Depth, and Central Corneal Power Measurements between Two Scheimpflug Imaging Systems2010

    • Author(s)
      Yuichi Hori, Yuzo Deguchi
    • Organizer
      2010 ASCRS Symposium & Congress
    • Place of Presentation
      The Boston Convention and Exhibition Center (USA)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 眼表面ムチンに対する市販多目的用剤および配合成分の影響2010

    • Author(s)
      今安正樹、堀裕一
    • Organizer
      第34回角膜カンファランス
    • Place of Presentation
      仙台
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム「ハードコンタクトレンズケースの管理」2009

    • Author(s)
      堀裕一
    • Organizer
      第52回日本コンタクトレンズ学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ハードコンタクトレンズ用洗浄保存液の抗菌効果について2009

    • Author(s)
      堀裕一、前田直之、井上智之、坂本雅子
    • Organizer
      第52回日本コンタクトレンズ学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム「角膜グライコバイオロジー」2009

    • Author(s)
      堀裕一
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 眼科学第2版「抗菌薬、抗ウイルス薬、抗真菌薬」2011

    • Author(s)
      堀裕一
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report
  • [Book] メディカルユースコンタクトレンズ.眼科診療クオリファイ6コンタクトレンズ自由自在2011

    • Author(s)
      堀裕一
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] ドライアイに対する治療.臨床眼科増刊号65(11)2011

    • Author(s)
      堀裕一
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 涙点プラグの使い分け.日本の眼科81(4)2010

    • Author(s)
      堀裕一
    • Publisher
      (社)日本眼科医会
    • Related Report
      2011 Final Research Report
  • [Book] 眼科診療クオリファイ2結膜炎オールラウンド「開発中のドライアイ治療薬について教えてください」2010

    • Author(s)
      堀裕一
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] メディカルユースソフトコンタクトレンズ2009

    • Author(s)
      堀裕一
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report
  • [Book] 外眼部常在菌2009

    • Author(s)
      堀裕一
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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