Effect of prostaglandin analogues on contraction and degradation of collagen gel mediated by human scleral fibroblasts

• Project/Area Number: 21791684
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Yamaguchi University
• Principal Investigator: SUZUKI Katsuyoshi Yamaguchi University, 医学部附属病院, 講師 (90325217)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 強膜線維芽細胞 / PG F2 / collagen gel / PGF2α / Collagen gel / PG F2α

Research Abstract

Prostaglandin analogues improve uveoscleral outflow, but its mechanism and physiology of uveoscleral outflow are still unknown. In this study, prostaglandin analogues induced collagen gel contraction mediated by human scleral fibroblasts. This action of prostaglandin analogues appeared to depend on the formation of stress fibers as well as the activation of mitogen-activated protein kinase, focal adhesion kinase, Rho-associated kinase in human scleral fibroblasts. Prostaglandin analogues might therefore influence scleral structure by affecting the contractility of scleral fibroblasts, resulting in improvement of uveoscleral outflow.

Research Products

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  • URL: http://ds.cc.yamaguchi-u.ac.jp/~eye/