|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
A recurrent murine model of uveitis was established. The main infiltrating cells into anterior chamber were neutrophils at day 1 and macrophages/monocytes at day 5 in the eyes with endotoxin-induce uveitis. A microarray analysis using RNA extracted from iris-ciliary body with EIU at day 1, 3, 5, and 7 was done. Over 1, 300 genes were significantly up-or down-regulated compared with those in normal eyes. The expression pattern was divided 7 clusters.