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Disclosure of continuation and interrelationship between Muller's muscle and intraorbital smooth muscles

Research Project

Project/Area Number 21791720
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionAichi Medical University

Principal Investigator

KAKIZAKI Hirohiko  Aichi Medical University, 医学部・眼科学講座, 准教授 (20329783)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsミュラー筋 / 内直筋 / 外直筋 / 滑車構造 / 線維連絡
Research Abstract

Purpose : This study was performed to examine Muller's muscle's horizontal extensions in relation to the peribulbar smooth muscle network.
Participants : Twenty postmortem orbits (10 right, 10 left) of 15 Asians (8 males, 7 females, aged 61 to 93 years at death; mean age : 78.4 years), fixed in 10% buffered formalin.
Methods : After performing a full-thickness 360 degrees incision of the periosteum around the circumference of the orbit, the periosteum was elevated and finally detached near to the orbital apex. Nerves, blood vessels and the nasolacrimal duct arising from the orbital wall were cut. The lateral orbital wall was then removed at approximately 3 cm posterior to the orbital rim and the retrobulbar content was incised with a sharp scalpel in a coronal plane. The removed orbital content was incised at a plane passing from a point located 15 mm superior to the upper eyelid margin and the globe equator at 3 and 9 o'clock areas. The sliced specimens were dehydrated and embedded in paraffin, cut into 7 μm thickness sections, and then stained with Masson Trichrome.
Results : In all specimens, Muller's muscle extended medially and laterally. The medial extension reached the medial rectus muscle pulley which is rich in smooth muscle fibers. The lateral extension reached the lateral rectus muscle pulley by passing through the lacrimal gland fascia of the palpebral lobe, in which 12 specimens also showed a direct extension to the lateral rectus muscle pulley in the posterior part.
Conclusions : Muller's muscle has a medial and a lateral extensions to the peribulbar smooth muscle network. These new findings indicated that Muller's muscle is not an independent structure in the upper eyelid but rather a component of the peribulbar smooth muscle network.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Muller's muscle : a component of the peribulbar smooth muscle network.2010

    • Author(s)
      Kakizaki H, Takahashi Y, Nakano T, Asamoto K, Ikeda H, Selva D, Leibovitch I.
    • Journal Title

      Ophthalmology. 117(11)

      Pages: 2229-2232

    • Related Report
      2010 Final Research Report
  • [Journal Article] Muller's muscle : A component of the peribulbar smooth muscle network

    • Author(s)
      Hirohiko Kakizaki et al.
    • Journal Title

      Ophthalmology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anatomy of the Upper, Lower, Medial and Lateral Eyelid Retarctors.2011

    • Author(s)
      Hirohiko Kakizaki.
    • Organizer
      Asia Pacific Academy of Ophthalmology.
    • Year and Date
      2011-03-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Anatomy of the Upper, Lower, Medial and Lateral Eyelid Retarctors2011

    • Author(s)
      Hirohiko Kakizaki
    • Organizer
      Asia Pacific Academy of Ophthalmology
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anatomy of the Upper, Lower, Medial and Lateral Eyelid Retarctors.2010

    • Author(s)
      Hirohiko Kakizaki.
    • Organizer
      The 8^<th> Congress of Eastern Cosmetic Surgery.
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Eyelid Anatomy : an Update2010

    • Author(s)
      Hirohiko Kakizaki
    • Organizer
      The 8^<th> Congress of Eastern Cosmetic Surgery
    • Place of Presentation
      ソウル(大韓民国)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Eyelid Anatomy : an Update.2010

    • Author(s)
      Hirohiko Kakizaki.
    • Organizer
      Asia Pacific Academy of Ophthalmology.
    • Year and Date
      2010-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Eyelid Anatomy Updated2010

    • Author(s)
      Hirohiko Kakizaki
    • Organizer
      Asia Pacific Academy of Ophthalmology
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Eyelid Anatomy : an Update.2010

    • Author(s)
      Hirohiko Kakizaki.
    • Organizer
      The World Ophthalmology Congress.
    • Year and Date
      2010-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Eyelid Anatomy : an Update2010

    • Author(s)
      Hirohiko Kakizaki
    • Organizer
      The World Ophthalmology Congress
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamic study of the medial and lateral recti capsulopalpebral fasciae using cine mode magnetic resonance imaging.2009

    • Author(s)
      Hirohiko Kakizaki.
    • Organizer
      ヨーロッパ眼形成再建外科学会.
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Dynamic study of the medial and lateral recti capsulopalpebral fasciae using cine mode magnetic resonance imaging2009

    • Author(s)
      Hirohiko Kakizaki
    • Organizer
      ヨーロッパ眼形成再建外科学会
    • Place of Presentation
      マルセイユ(フランス)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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