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Role of P75NTR in peripheral nerve regeneration

Research Project

Project/Area Number 21791743
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionOsaka University

Principal Investigator

HATA Yuki  大阪大学, 医学部附属病院, 医員 (10351058)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords末梢神経再生 / p75NTR / シュワン細胞 / 創傷治癒 / 線維芽細胞
Research Abstract

Double transgenic mice without P75NTR and with GFP expression in S-100 protein was successfully created. We invented the way to visualize myelin sheath regeneration by peripheral nerve transplantation. In addition, we proved that lack of p75 Low Affinity Nerve Growth Factor Receptor(p75NTR) impairs the migration, proliferation and the differentiation to miofibroblasts in fibroblasts of mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Presentation (3 results)

  • [Presentation] p75ニューロトロフィン受容体欠損マウス線維芽細胞における筋線維芽細胞への分化の評価2010

    • Author(s)
      波多祐紀
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] P75ニューロトロフィン受容体欠損マウスにおける線維芽細胞への影響2009

    • Author(s)
      波多祐紀
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] p75ニューロトロフィン受容体欠損マウスにおける線維芽細胞への影響2009

    • Author(s)
      波多祐紀
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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