Systematic pressure measurement and histological analysis of rat Lymphedema model and LVA model

Research Project

Project/Area Number	21791749
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Plastic surgery
Research Institution	Dokkyo Medical University
Principal Investigator	NOMURA Hiroshi Dokkyo Medical University, 医学部, 助教 (40513213)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords	外科 / 臨床 / 病理学 / 動物 / 応用動物・マイクロサージェリー学 / 応用動物
Research Abstract	We made Lewis rat Lymphedema model, by ring-shaped excision of subcutaneous tissue of unilateral hind limb. And we measured circumference, volume, and systematic pressure of rat hind limb before and after producing Lymphedema model. The average measurements before producing Lymphedema model was as follows : circumference 7.3±1.2cm, volume 8.4±5.7ml, and systematic pressure 10.5±2.9mmHg. The average measurements two weeks after producing Lymphedema model was as follows : circumference 7.2±2.1cm, volume 10.4±3.8ml, and systematic pressure 12.5±3.1mmHg.Volume and systematic pressure increased after producing Lymphedema model.