Regulation of mesenchymal stem cells in vivo by endogenous electric fields
| Project/Area Number |
21791755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
MABUCHI Yo Keio University, 医学部, 助教 (50424172)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 創傷治癒学 / 間葉系幹細胞 / 細胞移植 / 再生医学 / 移植・再生医療 / 細胞・組織 / 幹細胞制御 |
|---|
| Research Abstract |
Wound healing is essential for maintaining the integrity of multicellular organisms. It is thought that Mesenchymal Stem Cells (MSCs) were concerned with wound healing, however because MSCs have only been isolated from tissue in culture, the equivalent cells have not been identified in vivo. In this study, we performed a comprehensive screening of putative surface markers in order to select those that are most predictive of a pure MSC population in hBM. The transplant of the human MSCs enabled to analyze the migration of the human MSCs after the injury in vivo. Isolation technology of human MSC can analyze pure stem cell itself and elucidation of wound healing by an imaging technology.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Purified mesenchymal stem cells are an efficient source for iPS cell induction.2011
Author(s)
Kunimichi Niibe, Yoshimi Kawamura, Daisuke Araki, Satoru Morikawa, Kyoko Miura, Sadafumi Suzuki, Shigeto Shimmura, Takehiko Sunabori, Yo Mabuchi, Yasuo Nagai, Taneaki Nakagawa, Hideyuki Okano, Yumi Matsuzaki
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Journal Title
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Peer Reviewed
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[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
Author(s)
T S himizu, T Ishikawa, E Sugihara S Kuninaka, T Miyamoto, Y Mabuchi, Y Matsuzaki, T Tsunoda, F Miya, H Morioka, R Nakayama, E Kobayashi, Y Toyama, A Kawai, H Ichikawa, T Hasegawa, S Okada, T Ito, Y Ikeda, T Suda, H Saya
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Journal Title
Oncogene 29(42)
Pages: 5687-5699
Related Report
Peer Reviewed
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[Presentation] PROSPECTIVE CLONAL ISOLATION OF HUMAN MESENCHYMAL STEM CELLS ELUCIDATES HETEROGENEITY WITHIN THE MULTI-POTENT STEM CELL COMPARTMENT2010
Author(s)
Mabuchi, Yo (発表者), Morikawa, Satoru, Suzuki, Sadafumi, Lein, Lawrence, Niibe, Kunimichi, Nagai, Yasuo, Sunabori, Takehiko, Okano, Hideyuki, Matsuzaki, Yumi
Organizer
International Society for Stem Cell Research (ISSCR), 8th ANNUAL MEETING
Place of Presentation
San Francisco
Related Report
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[Presentation] PROSPECTIVE CLONAL ISOLATION OF HUMAN MESENCHYMAL STEM CELLS ELUCIDATES HETEROGENEITY WITHIN THE MULTI-POTENT STEM CELL COMPARTMENT2010
Author(s)
Mabuchi, Yo(発表者), Morikawa, Satoru, Suzuki, Sadafumi, Lein, Lawrence, Niibe, Kunimichi, Nagai, Yasuo, Sunabori, Takehiko, Okano, Hideyuki, Matsuzaki, Yumi
Organizer
第8回幹細胞シンポジウム
Place of Presentation
淡路島
Related Report
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