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Production of immortalized neuronal stem cells by Sox6-transfection and application to reproduction of a central nervous system

Research Project

Project/Area Number 21791761
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionKobe Gakuin University

Principal Investigator

HAMADA Michiko (HAMADA KANAZAWA Michiko)  神戸学院大学, 薬学部, 助教 (10248106)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経幹細胞 / Sox6 / apoptosis / Apoptosis / Sox2 / ES細胞 / Wnt-1
Research Abstract

Sox6 promotes the increase in the probability of survival, and the differentiation to neuron not only in neuroblast but also in neural stem cells. Especially, survival of a neural stem cell derived early stage of neurogenesis can be complemented with the member of other Sox family, but Survival remarkably decreased by Sox6 is knocked down in a neural stem cell derived later stage of neurogenesis. It suggested that Sox6 is mainly factor for survival of the neural stem cell of this stage. Further, we found some candidates of target genes of Sox6, that promote survival and neural differentiation of neural stem cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] β-Citryl-L-glutamate acts as an iron carrier to activate aconitase activity2011

    • Author(s)
      濱田美知子(1番目)、三宅正治, 他3名
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34(9) Pages: 1455-64

    • URL

      http://dx.doi.org/10.1248/bpb.34.1455

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] .BETA.-Citryl-L-glutamate Acts as an Iron Carrier to Activate Aconitase Activity2011

    • Author(s)
      濱田美知子
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 9 Pages: 1455-1464

    • DOI

      10.1248/bpb.34.1455

    • NAID

      130001872440

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superoxide scavenging and xanthine oxidase inhibiting activities of copper-β-citryl-L-glutamate complex2010

    • Author(s)
      楢原正則、濱田美知子(2番目)、三宅正治, 他2名
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 33(12) Pages: 1938-1943

    • URL

      http://dx.doi.org/10.1248/bpb.33.1938

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-Citryl-L-glutamate Is an Endogenous Iron Chelator That Occurs Naturally in the Developing Brain2010

    • Author(s)
      濱田美知子(1番目)、甲田真紀子、三宅正治, 他5名
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 33(5) Pages: 729-737

    • URL

      http://dx.doi.org/10.1248/bpb.33.729

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-Citryl-L-glutamate is endogenous iron chelator that occurs naturally in the developing brain2010

    • Author(s)
      Michiko Hamada-Kanazawa
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 729-737

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superoxide scavenging and Xanthine oxdase inhibiting activities of Copper-β-Citryl-L-glutamate complex2010

    • Author(s)
      Masanori Narahara
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 1938-1943

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胚性腫瘍細胞P19の神経分化におけるSox6の標的遺伝子の検索2011

    • Author(s)
      濱田美知子
    • Organizer
      日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経幹細胞の神経分化におけるSox6の役割2011

    • Author(s)
      中道絢子
    • Organizer
      日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 胚性幹細胞の神経分化におけるSox6の役割2011

    • Author(s)
      高橋亜里紗
    • Organizer
      日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 胚性腫瘍細胞P19の神経分化におけるSox6の標的遺伝子の検索2011

    • Author(s)
      濱田美知子
    • Organizer
      日本薬学会近畿支部
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経幹細胞の神経分化におけるSox6の役割2011

    • Author(s)
      中道絢子
    • Organizer
      日本薬学会近畿支部
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] The mechanism of survival by Sox6 during differentiation of neural stem cell2010

    • Author(s)
      濱田美知子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] The mechanism of survival by Sox6 during differentiation of neural stem cell.2010

    • Author(s)
      濱田美知子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胚性腫瘍細胞P19の神経分化におけるSox6とその標的遺伝子Wnt-1の働き2010

    • Author(s)
      濱田美知子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山総合体育館
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 胚性腫瘍細胞P19の神経分化におけるSox6とその標的遺伝子Wnt-1の働き2010

    • Author(s)
      濱田美知子
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山総合体育館
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sox6 promote neuronal differentiation in mouse neuronal stem cells2009

    • Author(s)
      濱田美知子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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