Production of immortalized neuronal stem cells by Sox6-transfection and application to reproduction of a central nervous system
| Project/Area Number |
21791761
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
HAMADA Michiko (HAMADA KANAZAWA Michiko) 神戸学院大学, 薬学部, 助教 (10248106)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経幹細胞 / Sox6 / apoptosis / Apoptosis / Sox2 / ES細胞 / Wnt-1 |
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| Research Abstract |
Sox6 promotes the increase in the probability of survival, and the differentiation to neuron not only in neuroblast but also in neural stem cells. Especially, survival of a neural stem cell derived early stage of neurogenesis can be complemented with the member of other Sox family, but Survival remarkably decreased by Sox6 is knocked down in a neural stem cell derived later stage of neurogenesis. It suggested that Sox6 is mainly factor for survival of the neural stem cell of this stage. Further, we found some candidates of target genes of Sox6, that promote survival and neural differentiation of neural stem cells.
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Report
(4 results)
Research Products
(16 results)
