Elucidation of the intracellular mechanisms about antiimflammatory and anticoagulative effects by ghrelin, and its application of therapy for venous thromboembolism

• Project/Area Number: 21791773
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Emergency medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: FUKAZAWA Madoka Kyoto Prefectural University of Medicine, 医学部附属病院, 専攻医 (30530357)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 周術期管理学 / 遺伝子治療 / 静脈性血栓塞栓症 / RNA干渉法

Research Abstract

We have demonstrated the modification of tissue factor expression on THP-1 cell and mouse monocyte-macrophage by knocking down GHS-R, leptin-r, ERk-1. With injection of these gene knocked down monocytes, survival and severity of pulmonary embolism have modified in mouse experimental model. Further studies are necessary to undergo detail analyses.

Research Products

• [Journal Article] 小児悪性腫瘍患者の痺痛管理 (2009)
  • Author(s): 深澤まどか、細川豊史、深澤圭太、上野博司, 大西佳子
  • Journal Title: 日本ペインクリニック学会誌 16:3 Pages: 408-408
  • Peer Reviewed
• [Presentation] 小児悪性腫瘍患者の痺痛管理 (2009)
  • Author(s): 深澤まどか, 細川豊史, 深澤圭太, 上野博司, 大西佳子, 須藤由香里, 原田秋穂, 清水文浩, 柿原健
  • Organizer: 日本ペインクリニック学会第43回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-18
• [Presentation] 頭頸部がん患者の痺痛管理 (2009)
  • Author(s): 深澤圭太, 細川豊史, 上野博司, 大西佳子, 須藤由香里, 原田秋穂, 清水文浩, 深澤まどか, 柿原健
  • Organizer: 日本ペインクリニック学会第43回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-17
• [Book] 神経ブロック・鍼療法(細川豊史・石丸圭荘編著)
  • Author(s): 大西佳子・山下智充・小西千陽・深澤圭太・大森美佐子・上野博司・深澤まどか・高取真由美・柿原健・原田秋穂 著
  • Publisher: 医歯薬出版株式会社