Examination of the efficacy of high-dose immunoglobulin in a rat model of sepsis
Project/Area Number |
21791776
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Emergency medicine
|
Research Institution | Keio University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 集中治療学 / 救急治療医学 |
Research Abstract |
Treatment with immunoglobulin significantly improved survival rate at postoperative day 7 (73% in the high-dose group vs. 33% in the control group ; p=0.037). The serum creatinine and blood urea nitrogen levels were significantly lower in the high-dose group than in the other groups. The serum HMGB1 level had increased at 4 hours postoperatively in the control group (10.2±3.3 ng/ml) and low-dose group (10.3±4.0 ng/ml), but it was significantly reduced in the high-dose group (4.2±0.8 ng/ml) compared to the control group (p=0.03). Our results suggest that high-dose immunoglobulin therapy might improve the pulmonary pathology and overall survival rate in sepsis by inhibiting the inflammation.
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Report
(3 results)
Research Products
(2 results)