Effect of diet-induced obesity and its immuno-defect on sublingual immunotherapy.
Project/Area Number |
21791781
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
|
Research Institution | Tohoku University |
Principal Investigator |
NAGAI Yasuhiro Tohoku University, 大学院・歯学研究科, 助教 (90508962)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 免疫 / 肥満 / アレルギー / 舌下免疫 / 金属アレルギー / 食事性肥満 / 免疫寛容 / 免疫不応答 |
Research Abstract |
Evidence from population studies shows that obesity clearly exacerbates a health risk. In this study we investigated the effects of diet-induced obesity on nickel allergy and anaphylactic shock and obtained the results below ; 1. Diet-induced obesity significantly reduced nickel allergy reaction. 2. Sublingual immunotherapy significantly reduces nickel allergy in normal mice, but there is no difference in obesity mice. OVA-induced anaphylactic shock did not occur in obesity mice.
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Report
(3 results)
Research Products
(17 results)