The study of regulation of bone metabolism and hematopoietic stem cell niche by steroid hormone and these target factors
Project/Area Number |
21791787
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Morphological basic dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
HIYAMA Shinji Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (60314754)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 骨代謝 / エストロゲン / 幹細胞ニッチ / 骨髄骨 / 破骨細胞 / 骨リモデリング / 骨芽細胞 |
Research Abstract |
To clarify the regulation of mechanism of bone metabolism and hematopoietic stem cell niche by estrogen, we used the medullary bone formation model of estrogen-treated male Japanese quails. Medullary bone remodeling was under the control of OPG/RANKL/RANK system. During medullary bone formation period, the population of bone marrow cells shifts from undifferentiated cells to osteoclast precursor cells and osteoblasts on the medullary bone act as a niche cells. These results suggest that estrogen may be related to regulate of hematopoietic stem cell niche.
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Report
(3 results)
Research Products
(13 results)