Development of hyposensitization therapy applying the recombinant oral bacteria secreting the allergen of hey fever.
| Project/Area Number |
21791798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
KUWAHARAN Oriko Nihon University, 松戸歯学部, 講師 (90287665)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔細菌学 / アレルギー / スギ花粉症 / 減感作療法 / 組換え体 / 組み換え体 |
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| Research Abstract |
In this application, i) "Construction of recombinant Streptococcus anginosus strain which can express stabilizing the recombinant allergen of hay fever caused by cedar pollen" and ii) "Colonization of the recombinant S. anginosus, and the induction of immune response mechanism against allergen of hay fever caused by cedar pollen which secreted from recombinant bacteria using the laboratory animal" were examined.
The aim i) was accomplished, but the aim ii) was underway.
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Report
(3 results)
Research Products
(8 results)
