Molecular Mechanism of DEC2 and VEGF in cancer
| Project/Area Number |
21791801
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
BHAWAL Ujjal Kanagawa Dental College, 歯学部, プロジェクト研究員 (50433339)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 時計遺伝子 / DEC / VEGF / 口腔扁平上皮癌 / 低酸素 |
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| Research Abstract |
Basic-helix-loop-helix (bHLH) transcription factors DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are significantly up-regulated in various types of cancers, and transfection with DEC1 or DEC2 decreases cell proliferation, apoptosis of tumor cells. We showed that DEC overexpression exhibits delayed wound healing and reduces cell proliferation, migration and invasion. Therefore, DEC is considered to be an attractive target for anticancer therapy.
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Report
(3 results)
Research Products
(27 results)
