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Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and trafficking

Research Project

Project/Area Number 21791806
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

HASEGAWA Takahiro  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (50447273)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsアクアポリン / 翻訳後修飾 / リン酸化 / ユビキチン化 / 細胞内膜輸送 / 唾液腺 / アクアポリン5 / アクアポリン5(AQP5) / 細胞内輸送
Research Abstract

Two types of posttranslational modification (phosphorylation and ubiquitination) of water channel aquqaporin-5 (AQP5) were found in mouse salivary gland cells. AQP5 was transiently ubiquitinated and phosphorylated through the stimulation of intracellular Ca^<2+> signaling and the cAMP signaling, respectively. Our present study reveals that the posttranslational modifications of AQP5 are involved in the saliva secretion that is regulated by sympathetic and parasympathetic nervous systems.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats2011

    • Author(s)
      Karabasil MR, Hasegawa T, Hosoi K (他5名, 2番目)
    • Journal Title

      Biol Cell 103

      Pages: 69-86

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats.2011

    • Author(s)
      Karabasil Ratko Mileva, et al.
    • Journal Title

      Biology of the cell

      Volume: 103 Pages: 69-86

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation2010

    • Author(s)
      Azlina A, Hasegawa T, Hosoi K.(他4名, 4番目)
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kB and p-c-Jun/c-Fos.2010

    • Author(s)
      Yao C, Hasegawa T, Hosoi K.(他7名, 6 番目)
    • Journal Title

      Am J Pathol 177

      Pages: 724-734

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos.2010

    • Author(s)
      Yao Chenjuan, et al.
    • Journal Title

      The American journal of pathology

      Volume: 177 Pages: 724-734

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chords tympani parasympathetic denervation.2010

    • Author(s)
      Azlina Ahmad, et al.
    • Journal Title

      American journal of physiology, Gastrointestinal and liver physiology

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking.2009

    • Author(s)
      Karabasil, et al.
    • Journal Title

      The Journal of Medical Investigation 56 Suppl.

      Pages: 398-400

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats.2009

    • Author(s)
      Azlina, et al.
    • Journal Title

      The Journal of Medical Investigation 56 Suppl.

      Pages: 273-276

    • Related Report
      2009 Annual Research Report
  • [Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010

    • Author(s)
      長谷川敬展
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010

    • Author(s)
      長谷川敬展、アズリナアハマド、ジャフランフルジャフ、廣島佑香、姚陳娟、赤松徹也、細井和雄
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京都
    • Related Report
      2010 Final Research Report
  • [Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009

    • Author(s)
      長谷川敬展
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009

    • Author(s)
      長谷川敬展、アズリナアハマド、ジャフランフルジャフ、姚陳娟、赤松徹也、細井和雄
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟市
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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