Identification of drug-metabolizing enzymes associated with human tongue carcinogenesis using genetic polymorphisms

• Project/Area Number: 21791827
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kagoshima University
• Principal Investigator: HIRANO Masato 鹿児島大学, 大学院・医歯学総合研究科, 助教 (70381184)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 舌癌 / 薬物代謝酵素 / 遺伝子多型

Research Abstract

We have recently reported that a genetic polymorphism of the type II detoxifying enzyme NQO1 may be a major determinant of the susceptibility of rats to oral squamous-cell carcinoma(OSCC) induced by 4-nitroquinoline 1-oxide(4NQO). To test whether this is also the case in human OSCC, polymorphisms of NQO1, CYP1A1 and GSTP1 were examined in a population-based case-control study. In NQO1 and CYP1A1, the homozygous-variant type was much less common among the subjects in the control group than it was among the OSCC cases. Alternatively, GSTP1 have not yet been completely characterised.

Research Products

• [Journal Article] FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma (2010)
  • Author(s): Tanuma J, Izumo T, Hirano M, Oyazato Y, Hori F, Umemura E, Shisa H, Hiai H, Kitano M.
  • Journal Title: Oncol Rep Volume: 23(3) Pages: 739-44
  • Peer Reviewed