A novel osteoimmunological approach to identify the role of bone resident macrophages and the osteonecrosis of the jaw
| Project/Area Number |
21791834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka Dental University |
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Principal Investigator |
DOMAE Eisuke Osaka Dental University, 歯学部, 助教 (50454559)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マクロファージ / 破骨細胞 |
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| Research Abstract |
In this experiment bisphosphonates reduced the adherent strength of osteoclast precursors which are in the process of osteoclast differentiation. Because antibody against adhesion molecules altered osteoclastgenesis, I tried to find the signaling molecules which integrate adhesion molecules and osteoclastgenesis. Syk and Fyn, tyrosine kinases known to be important for osteoclastgenesis, were co-immunoprecipitated with integrins in the process of osteoclastgenesis. These results suggest that outside-in signals from integrins are important for osteoclast-precursor function and differentiation.
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Report
(3 results)
Research Products
(8 results)
