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Development of the novel noninvasive bone augmentation technique

Research Project

Project/Area Number 21791907
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Prosthetic dentistry
Research InstitutionKyushu University

Principal Investigator

JINNO Yohei  Kyushu University, 歯学研究院, 助教 (40507779)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨増生 / 歯科用インプラント / スタチン / 非侵襲 / 骨
Research Abstract

Within the limitation of our study, we suggest that a single-shot percutaneous injection of fluvastatin with a collagen-α-tricalcium phpsphate (αTCP) composite induces new bone formation in a vertical direction around and under the composite(calvarial bone of rat). However, it is very difficult to obtain new bone on the alveolar bone (rat, dog). Further study is needed for clinical application. (ideal concentration of fluvastatin, investigation of the novel drug delivery system)

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Vertical bone augmentation with fluvastatin in an injectable delivery system : a rat study.2009

    • Author(s)
      Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyaka Y, Koyano K
    • Journal Title

      Clin Oral Implants Res 8

      Pages: 756-760

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid)microspheres on osteogenesis around titanium implants in rat tibiae.2009

    • Author(s)
      Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K
    • Journal Title

      Biomaterials 12

      Pages: 3327-3334

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae.2009

    • Author(s)
      Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K
    • Journal Title

      J Oral Rehabil 2

      Pages: 123-130

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vertical bone augmentation with fluvastatin in an injectable delivery system : a rat study.2009

    • Author(s)
      Jinno Y, et al
    • Journal Title

      Clin Oral Implants Res 8

      Pages: 756-760

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The eddect of a single remote injection of statin-impregnated poly (lactiv-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia.2009

    • Author(s)
      Masuzaki T, et al
    • Journal Title

      Biomaterials 12

      Pages: 3327-3334

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae.2009

    • Author(s)
      Ayukawa Y, et al.
    • Journal Title

      J Oral Rehabil 2

      Pages: 123-130

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A New Statin Delivery System to Improve the Bone Thickness2009

    • Author(s)
      Jinno Y, et al
    • Organizer
      5th Scientific Meeting Asian Academy of Osseointegration
    • Place of Presentation
      インドネシア バリ
    • Related Report
      2010 Final Research Report
  • [Presentation] A New Statin Delivery System to Improve the Bone Thickness2009

    • Author(s)
      Jinno Y, et al
    • Organizer
      5^<th> Scientific Meeting Asian Academy of Osseointegration
    • Place of Presentation
      インドネジア バリ
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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