Development of reconstruction scaffold for jaw bone made of titanium fiber web with cell induction ability

• Project/Area Number: 21791945
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Yokohama City University
• Principal Investigator: HIROTA Makoto Yokohama City University, 医学部, 准教授 (20347305)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: チタンファイバー / 顎骨再建 / 生体材料 / アパタイト / ハイドロキシアパタイトコーティング

Research Abstract

The aim of this study was evaluation of the bone regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. A thin HA film was uniformly coated on a TW by the molecular precursor method, without affecting the structure of the TW. Human osteoblasts culture on TW and HA-coated TW (HA/TW) suggested that the HA coated by the molecular precursor method maintained TW architecture and accelerated osteoblast differentiation. Then, TW discs with or without thin HA coating were implanted into rat cranial cortical bone defects, suggesting a thin HA coating enhanced the cortical bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW 3-dimensional scaffold.

Research Products

• [Journal Article] Apatite coated titanium fiber web accelerates human osteoblast functional activity. (2011)
  • Author(s): Hirota M, Hayakawa T, Ametani A, 他3名
  • Journal Title: International Journal of Oral and Maxillofacial Implnats 26
• [Journal Article] The effect of hydroxyapatite-coated titanium fiber web on human osteoblast functional activity. (2011)
  • Author(s): Hirota M, Hayakawa T, Ametani A, Kuboki Y, Sato M, Tohnai I
  • Journal Title: International Journal of Oral and Maxillofacial Implants Volume: 26 Pages: 245-250
  • Peer Reviewed
• [Journal Article] Molecular precursor method facilitates thin hydroxyapatite coating of titanium fiber web scaffold and enhances bone formation : Experimental study in rat cranial bone defects. (2010)
  • Author(s): Hirota M, Hayakawa T, Ametani A, 他3名
  • Journal Title: International Journal of Oral and Maxillofacial Implnats 25 Pages: 888-892
• [Journal Article] Use of the molecular precursor method to facilotate thin hydroxyapatite coating titanium fiber web scaffold and enhance bone formation : an experimental study in rat cranial bone defects. (2010)
  • Author(s): Hirota M, Hayakawa T, Ametani A, Monden Y, Noishiki Y, Tohnai I
  • Journal Title: International Journal of Oral and Maxillofacial Implants Volume: 25 Pages: 888-892
  • Peer Reviewed