• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of the pathogenic roles of Toll-like receptor and regulatory T cell in oral candidiasis

Research Project

Project/Area Number 21791963
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

HATA Hironobu  Hokkaido University, 大学院・歯学研究科, 助教 (70450830)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords病態検査学 / 口腔カンジダ症 / Toll様受容体 / 自然免疫 / 制御性T細胞 / 動物モデル
Research Abstract

A case-control study of oral candidiasis was undertaken to determine the TLR2 expression in peripheral blood mononuclear cells, and to assess the inflammatory cytokine production capacity of TLR2.
As a result we found that : (1) there was no significant difference in TLR2 expression and TLR function between oral candidiasis and the control, and (2) the TLR2 level was remarkably low in refractory oral candidiasis compared with curable oral candidiasis. These results suggest that a low level of TLR2 is related to refractoriness of oral candidiasis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

Research Products

(22 results)

All 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Associations between self-assessed masticatory ability and higher brain function among the elderly.2011

    • Author(s)
      Moriya S, Hata H
    • Journal Title

      Journal of Oral Rehabilitation. Epub ahead of print(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between perceived chewing ability and muscle strength of the body among the elderly.2011

    • Author(s)
      Moriya S, Hata H
    • Journal Title

      Journal of Oral Rehabilitation Epub ahead of print(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 集学的治療におけるサポートシステム歯科的サポート2011

    • Author(s)
      秦浩信
    • Journal Title

      JOHNS 27(4)

      Pages: 619-623

    • Related Report
      2010 Final Research Report
  • [Journal Article] がん患者をサポートする口腔ケア 急性期の口腔ケア:頭頸部がんの場合2011

    • Author(s)
      秦浩信
    • Journal Title

      DH Style 5

      Pages: 56-60

    • Related Report
      2010 Final Research Report
  • [Journal Article] Associations between self-assessed masticatory ability and higher brain function among the elderly.2011

    • Author(s)
      Moriya S
    • Journal Title

      Journal of Oral Rehabilitation.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between perceived chewing ability and muscle strength of the body among the elderly2011

    • Author(s)
      Moriya S
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集学的治療におけるサポートシステム 歯科的サポート2011

    • Author(s)
      秦浩信
    • Journal Title

      JOHNS

      Volume: 27(4) Pages: 619-623

    • Related Report
      2010 Annual Research Report
  • [Journal Article] がん患者をサポートする口腔ケア 急性期の口腔ケア:頭頸部がんの場合2011

    • Author(s)
      秦浩信
    • Journal Title

      DH style

      Volume: 5 Pages: 56-60

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Oral health care reduces the risk of postoperative surgical site infection in inpatients with oral squamous cell carcinoma.2010

    • Author(s)
      Sato J, Hata H
    • Journal Title

      Support Care Cancer 19(3)

      Pages: 409-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 根拠がわかる口腔ケア:頭頸部がん・食道がん周術期の局所合併症とその対処2010

    • Author(s)
      秦浩信
    • Journal Title

      がん看護 15

      Pages: 506-510

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oral health care reduces the risk of postoperative surgical site infection in inpatients with oral squamous cell carcinoma.2010

    • Author(s)
      Sato J
    • Journal Title

      Support Care Cancer

      Volume: 19(3) Pages: 409-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【根拠がわかる口腔ケア】頭頸部がん・食道がん周術期の局所合併症とその対処2010

    • Author(s)
      秦浩信
    • Journal Title

      がん看護

      Volume: 15 Pages: 506-510

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 【口腔内科学的アプローチの現在】大学病院における口腔ケアと医科との連携2010

    • Author(s)
      秦浩信
    • Journal Title

      歯科医療 24

      Pages: 25-32

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 20歳代の歯学部学生におけるカンジダ菌の保菌状況について2009

    • Author(s)
      村田翼
    • Journal Title

      日本口腔粘膜学会雑誌 15

      Pages: 1341-7983

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【病棟でもココまでできる口腔ケア実践ガイド】症状・状態別 口腔ケア応用編 がん患者の口腔ケア2009

    • Author(s)
      秦浩信
    • Journal Title

      ナーシングトゥディ 10

      Pages: 93-98

    • Related Report
      2009 Annual Research Report
  • [Presentation] A clinical study of patients with psychosomatic taste disorders2011

    • Author(s)
      Hata H
    • Organizer
      The American Academy of Oral Medicine
    • Place of Presentation
      San Juan Puerto Rico
    • Year and Date
      2011-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] A cinilal study of patients with psychosomatic taste disorders2011

    • Author(s)
      Hata H
    • Organizer
      The American Academy of Oral Medicine
    • Place of Presentation
      Puerto Rico(アメリカ)
    • Year and Date
      2011-04-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔カンジダ症における再発例の臨床的検討2009

    • Author(s)
      山崎裕
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔疾患を有する患者の末梢血単核球におけるToll様受容体の発現2009

    • Author(s)
      後藤隼, 秦浩信
    • Organizer
      歯科基礎学会
    • Place of Presentation
      朱鷺メッセ 新潟
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔疾患を有する患者の末梢血単核球における Toll 様受容体の発現2009

    • Author(s)
      後藤準
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 20歳代の歯学部学生におけるカンジダ菌の保菌状況について2009

    • Author(s)
      村田翼
    • Organizer
      日本口腔粘膜学会
    • Place of Presentation
      ロフォス湘南(葉山町)
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔カンジダ症予防における義歯への対処 培養検査によるオゾン水の義歯洗浄効果2009

    • Author(s)
      山崎裕
    • Organizer
      日本口腔科学会
    • Place of Presentation
      オークラアクトシティホテル浜松(浜松)
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi