Investigation of the pathogenic roles of Toll-like receptor and regulatory T cell in oral candidiasis
| Project/Area Number |
21791963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
HATA Hironobu Hokkaido University, 大学院・歯学研究科, 助教 (70450830)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 病態検査学 / 口腔カンジダ症 / Toll様受容体 / 自然免疫 / 制御性T細胞 / 動物モデル |
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| Research Abstract |
A case-control study of oral candidiasis was undertaken to determine the TLR2 expression in peripheral blood mononuclear cells, and to assess the inflammatory cytokine production capacity of TLR2.
As a result we found that : (1) there was no significant difference in TLR2 expression and TLR function between oral candidiasis and the control, and (2) the TLR2 level was remarkably low in refractory oral candidiasis compared with curable oral candidiasis. These results suggest that a low level of TLR2 is related to refractoriness of oral candidiasis.
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Report
(3 results)
Research Products
(22 results)
