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The analysis of multipotential immune cells induced in oral cancer patients for development of novel immunotherapy

Research Project

Project/Area Number 21791978
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA KAE  東京医科歯科大学, 歯学部附属病院, 助教 (20431934)

Project Period (FY) 2009-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords抗腫瘍免疫 / 口腔癌 / 腫瘍免疫 / 免疫回避機構 / 癌 / 免疫学 / 免疫抑制細胞
Research Abstract

We investigated Myeloid Derived Suppressor Cells induced in tumor-bearing mice after injection with transplantable oral squamous cell carcinoma, and clarified that GM-CSF is needed to maintain these cells. But, there is difference in quantity of these cells among oral cancer patients unlike mouse model using murine oral cancer cell line producing GM-CSF, which might be depending on quantity of GM-CSF produced by human oral cancer, because there is difference in GM-CSF production individually. The analysis of the relationship between these cells and GM-CSF production is currently under investigation, concomitantly with the analysis of expression levels of B7-H3 on tumor cells in oral cancer patients.

Report

(5 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] Myoepithelioma of the parotid gland presenting as a retroauricular cutaneous nodule: A case report.2013

    • Author(s)
      Mochizuki Y, Omura K, Tanaka K, Sakamoto K, Yamaguchi A
    • Journal Title

      J Clin Diagn Res

      Volume: 7 Pages: 1165-8

    • DOI

      10.7860/jcdr/2013/6037.3096

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔白板症の癌化に関する臨床的検討2013

    • Author(s)
      津島文彦, 桜井仁亨, 佐藤 昌, 須田悠里, 田中香衣, 富岡寛文, 島本裕彰, 中島雄介, 原田 浩之, 小村 健
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59 Pages: 691-8

    • NAID

      130004793863

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔内小唾液腺癌45例の臨床的検討2012

    • Author(s)
      田中香衣, 小村 健, 原田浩之, 岡田憲彦
    • Journal Title

      日本口腔腫瘍学会誌

      Volume: 24巻 Pages: 21-27

    • NAID

      10031168572

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔内小唾液腺癌45例の臨床的検討2012

    • Author(s)
      田中香衣, 他
    • Journal Title

      日本口腔腫瘍学会誌

      Volume: 24 Pages: 21-27

    • NAID

      10031168572

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ベーチェット病患者の舌背部に発生した扁平上皮癌の1例2011

    • Author(s)
      田中香衣, 他
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 57 Pages: 319-323

    • NAID

      10030272158

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 顎骨に発生したランゲルハンス細胞組織球症の3例2009

    • Author(s)
      田中香衣, 他
    • Journal Title

      頭頸部癌学会会誌 35

      Pages: 310-315

    • NAID

      10025607481

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Scapular osteofascioadipose flapによる下顎再建2011

    • Author(s)
      小村健, 他
    • Organizer
      日本口腔外科学会総会・学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における対側頚部リンパ節転移症例の検討2011

    • Author(s)
      富岡寛文, 他
    • Organizer
      第35回日本頭頚部癌学会
    • Place of Presentation
      愛知
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の臨床病理学的検討2011

    • Author(s)
      原田浩之, 他
    • Organizer
      第35回日本頭頚部癌学会
    • Place of Presentation
      愛知
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 治療前の外科処置が下顎歯肉扁平上皮癌に与える影響2011

    • Author(s)
      富岡寛文, 他
    • Organizer
      日本口腔腫瘍学会総会
    • Place of Presentation
      崇城大学市民ホール(熊本)
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] A clinicopathological study of intraoral minor salivary gland carcinomas2010

    • Author(s)
      K.Tanaka, et al.
    • Organizer
      9th Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Kuala Lumpur Convention Center (Malaysia)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小唾液腺癌37例の臨床病理学的検討2010

    • Author(s)
      田中香衣, 他
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌のpN別の治療成績2010

    • Author(s)
      原田浩之, 他
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] T1,2舌癌手術例の検討2010

    • Author(s)
      田中香衣, 他
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 治療前に外科処置が行われた上・下顎歯肉扁平上皮癌の検討2010

    • Author(s)
      富岡寛文, 他
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における遠隔転移発現に関与する因子の検討2009

    • Author(s)
      原田浩之, 他
    • Organizer
      日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頸部郭清術後頸部再発例の検討

    • Author(s)
      田中香衣、大迫利光、釘本琢磨、望月裕美、平井秀明、富岡寛文、島本裕彰、生田 稔、原田浩之、小村 健
    • Organizer
      第195回日本口腔外科学会関東支部学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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