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Identification of tumor antigens in squamous cell carcinoma of head and neck by SEREX to determin immunogenically ideal targets for patients.

Research Project

Project/Area Number 21791997
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

DOUMAE Shouhei  Okayama University, 大学院・医歯薬学総合研究科, 助教 (70397892)

Co-Investigator(Renkei-kenkyūsha) ONO Toshro  岡山大学, 自然生命科学研究支援センター, 准教授 (50185641)
UENAKA Akiko  岡山大学, 大学院・医歯薬学総合研究科, 講師 (50273967)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsCT抗原 / SEREX / 頭頸部癌 / CCDC62-2 / 腫瘍マーカー / SEREX解析
Research Abstract

SEREX-defined CCDC62-2 is a CT antigen that is immunogenic in a variety of cancer patients. We showed that CCDC62-2 is immunogenic in squamous cell carcinoma of head and neck (SCCHN) patients and its potential target for diagnostic reagent for SCCHN. To analyze CCDC62-2 protein expression in SCCHN, we produced a CCDC62-2 mAb. Immunohistochemical staining using a CCDC62-2 mAb showed that positive staining was observed heterogeneously in nuclei or cytoplasm of tumor cells. Humoral immune response of another SEREX-defined antigen, GKAP1, to a variety of cancer patients including SCCHN was examined. SCCHN patients produced antibody to GKAP1 protein, showing an additional candidate of the tumor marker for SCCHN.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] 他、CCDC62-2 expression in head and neck cancer and antibody response in patients2011

    • Author(s)
      銅前昇平
    • Organizer
      第29回口腔腫瘍学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2011-01-27
    • Related Report
      2010 Final Research Report
  • [Presentation] CCDC62-2 expression in head and neck cancer and antibody response inpatients2011

    • Author(s)
      銅前昇平
    • Organizer
      第29回口腔腫瘍学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規CT(がん・精巣)抗原CCDC62-2の同定とその免疫原性2010

    • Author(s)
      銅前昇平
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉幕張
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] SEREX法によるがん・精巣(CT)抗原CCDC62-2の同定とがん患者の液性免疫応答2010

    • Author(s)
      銅前昇平
    • Organizer
      第64回口腔科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://ousar.lib.okayama-u.ac.jp/metadata/16862

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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