Identification of tumor antigens in squamous cell carcinoma of head and neck by SEREX to determin immunogenically ideal targets for patients.
| Project/Area Number |
21791997
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
DOUMAE Shouhei Okayama University, 大学院・医歯薬学総合研究科, 助教 (70397892)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Toshro 岡山大学, 自然生命科学研究支援センター, 准教授 (50185641)
UENAKA Akiko 岡山大学, 大学院・医歯薬学総合研究科, 講師 (50273967)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | CT抗原 / SEREX / 頭頸部癌 / CCDC62-2 / 腫瘍マーカー / SEREX解析 |
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| Research Abstract |
SEREX-defined CCDC62-2 is a CT antigen that is immunogenic in a variety of cancer patients. We showed that CCDC62-2 is immunogenic in squamous cell carcinoma of head and neck (SCCHN) patients and its potential target for diagnostic reagent for SCCHN. To analyze CCDC62-2 protein expression in SCCHN, we produced a CCDC62-2 mAb. Immunohistochemical staining using a CCDC62-2 mAb showed that positive staining was observed heterogeneously in nuclei or cytoplasm of tumor cells. Humoral immune response of another SEREX-defined antigen, GKAP1, to a variety of cancer patients including SCCHN was examined. SCCHN patients produced antibody to GKAP1 protein, showing an additional candidate of the tumor marker for SCCHN.
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Report
(3 results)
Research Products
(5 results)
