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Development of the inhibition therapy against growth and metastasis of oral cancer targeting CXC chemokine, SDF-1

Research Project

Project/Area Number 21792003
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

UCHIDA Daisuke  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (20335798)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsSDF-1 / CXCR4 / 口腔癌 / 転移 / CXCR7 / AMD3100
Research Abstract

We have tried to inhibit both growth via CXCR7 and metastasis via CXCR4 by the inhibition of SDF-1 on the oral cancer cells. SDF-l antibody inhibited the anchorage independent growth of oral cancer cells in vitro, but did affect neither growth nor metastasis in vivo. However, a CXCR4 specific antagonist AMD3100 significantly inhibited the metastasis of oral cancer cells. These results indicated that inhibition of both CXCR4 and CXCR7 by the SDF-1 antibody is difficult, but AMD3100 may be a potent anti-metastatic therapy in cases of CXCR4-related oral cancer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases2011

    • Author(s)
      Uchida D, Onoue T, Kuribayashi N, Tomizuka Y, Tamatani T, Nagai H, Miyamoto Y.
    • Journal Title

      Eur J Cancer 47

      Pages: 452-459

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases.2011

    • Author(s)
      Uchida D, et al.
    • Journal Title

      Eur J Cancer

      Volume: 47 Pages: 452-459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesnarinone downregulates CXCR4 expression via upregulation of Kruppel-like factor 2 in oral cancer cells.2009

    • Author(s)
      Uchida D
    • Journal Title

      Molecular Cancer 8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ケモカインレセプターCXCR4を介した唾液腺腺様嚢胞癌の転移機構2009

    • Author(s)
      内田大亮, 他
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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