Development of oral cancer therapy using anti cancer drug and siRNA against MSF, a novel angiogenic factor.
Project/Area Number |
21792005
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | The University of Tokushima |
Principal Investigator |
OOE Gou The University of Tokushima, 病院, 助教 (60432762)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 臨床腫瘍学 / Migration Stimulating Factor / 口腔癌 / 浸潤 / 血管新生 / Migration Stmulating Factor |
Research Abstract |
Migration Stimulating Factor (MSF) enhanced cancer progression by stimulating of cancer migration and angiogenic. In vitro study, combination therapy of siRNA against MSF (MSF siRNA) and anti cancer drug demonstrated additive effect. In vivo study, treatment with MSF siRNA only or combination therapy of MSF siRNA and anti cancer drug showed anti cancer effect against nudemice bearing B88, oral SCC.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Multi-functional modukation of IGD motogenic potential in MSF (migration stimulating factor).2010
Author(s)
Ellis IR, Jones SJ,Staunton D, Vakonakis I, Norman DG, PottsJR, Milner CM, Meenan NA, Raibaud S, Ohe G,Schor AM, Schor SL.
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Journal Title
Exp Cell Res 316
Pages: 2465-2476
Related Report
Peer Reviewed
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