A development of new treatment for oral cancer with beta4 integrin and associated proteins.

Research Project

Project/Area Number	21792011
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Ehime University
Principal Investigator	ARAMOTO Takayoshi Ehime University, 医学部附属病院, 助教 (00380220)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	beta4 integrin / ヘミデスモゾーム / siRNA / β4インテグリン / クラステリン
Research Abstract	We concluded that the inhibition of beta4 integrin which is the member of integrin family, can interaction with ECM, changed cell morphology, cell motility, and decreased cell invation in oral squamous cell lines. Our data suggested that beta4 integrin is greatly taken part in cancer cell invation.