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Analysis of the mechanism of metastasis mediated ADAM-17 in adenoid cystic carcinoma.

Research Project

Project/Area Number 21792018
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKumamoto University

Principal Investigator

TAKAMUNE Yasuo  Kumamoto University, 医学部附属病院, 医員 (50467982)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords腺様嚢胞癌 / 細胞接着 / プロテアーゼ / 癌の浸潤・転移 / 腺様襄胞癌
Research Abstract

We were cultured in Adenoid cystic carcinoma cells. In this study, After the effects of TNFα cytokines on CD44 cleavage were examined in several Adenoid cystic carcinoma cell lines using Western blotting . And we examined relationship between expression of ADAM17 and CD44 cleavage in mechanism for the tumor progression of ACC cell.
The treatment of ACC cells with TNFα did not induce the generation of CD44 cleaved.
We have to consider that cell lines after stimulation with TNFα, we are looking for localization of CD44 intracellular domain location details.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient.2010

    • Author(s)
      Yoshitake,Y., Nakayama,H., Takamune,Y., Yasunaga,M., Hiraki,A., Shinohara,M.
    • Journal Title

      Int J Oral Maxillofac Surg. vol40, No.1

      Pages: 120-123

    • Related Report
      2010 Final Research Report
  • [Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient.2010

    • Author(s)
      Yoshitake, Y.
    • Journal Title

      International Journal of Oral & Maxillofacial Surgery.

      Pages: 120-123

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 5-フルオロウラシル耐性口腔扁平上皮癌細胞の樹立とその細胞特性2009

    • Author(s)
      永田将士、中山秀樹、吉武義泰、田中拓也、吉田遼司、福間大喜、高宗康隆、尾木秀直、太田和俊、平木昭光、大林武久、篠原正徳
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト口腔扁平上皮癌細胞株を用いた5-FU 耐性株の樹立と機能解析2009

    • Author(s)
      永田将士、中山秀樹、田中拓也、吉武義泰、高宗康隆、福間大喜、吉田遼司、尾木秀直、篠原正徳
    • Organizer
      第33回日本頭頚部癌学会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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