Analysis of the mechanism of metastasis mediated ADAM-17 in adenoid cystic carcinoma.
| Project/Area Number |
21792018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKAMUNE Yasuo Kumamoto University, 医学部附属病院, 医員 (50467982)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 腺様嚢胞癌 / 細胞接着 / プロテアーゼ / 癌の浸潤・転移 / 腺様襄胞癌 |
|---|
| Research Abstract |
We were cultured in Adenoid cystic carcinoma cells. In this study, After the effects of TNFα cytokines on CD44 cleavage were examined in several Adenoid cystic carcinoma cell lines using Western blotting . And we examined relationship between expression of ADAM17 and CD44 cleavage in mechanism for the tumor progression of ACC cell.
The treatment of ACC cells with TNFα did not induce the generation of CD44 cleaved.
We have to consider that cell lines after stimulation with TNFα, we are looking for localization of CD44 intracellular domain location details.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient.2010
Author(s)
Yoshitake,Y., Nakayama,H., Takamune,Y., Yasunaga,M., Hiraki,A., Shinohara,M.
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Journal Title
Int J Oral Maxillofac Surg. vol40, No.1
Pages: 120-123
Related Report
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