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Expression analysis of SFRP family genes for development of molecular targeted therapy for oral cancer

Research Project

Project/Area Number 21792021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionSapporo Medical University

Principal Investigator

SOGABE Yohei  Sapporo Medical University, 医学部, 研究員 (50468104)

Co-Investigator(Renkei-kenkyūsha) OGI Kazuhiso  札幌医科大学, 医学部, 助教 (40433114)
HIRATSUKA Hiroyoshi  札幌医科大学, 医学部, 教授 (50165180)
TOKINO Takashi  札幌医科大学, 医学部, 教授 (40202197)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords臨床腫瘍学 / エピジェネティクス / 遺伝子 / 癌 / 歯学 / シグナル伝達
Research Abstract

In the present study, we examined the relationship between Wnt signaling and epigenetic alteration of the secreted frizzled-related protein (SFRP) genes in OSCC. Our results confirm the frequent methylation and silencing of SFRP genes in OSCC, and suggest that their loss of function contributes to activation of Wnt signaling that leads to cell proliferation during oral carcinogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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