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Autograft experiment of the induced bone on the periosteum by absorptive HAp/BMP-2 to mandibular resected region.

Research Project

Project/Area Number 21792027
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

HINO Jun  Health Sciences University of Hokkaido, 歯学部, 助手 (20508709)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords吸収性セラミックス / 生体材料 / 骨膜上骨誘導 / 骨移植 / 移植・再生医療 / 超音波部分溶解析出処理
Research Abstract

The supra-periosteal implant, of the biomimctic functionally graded hydroxyapatite (fg-HAp, absorptive HAp)/BMP-2 showed high cell proliferation activity and excellent hard tissue induction. Moreover, it was suggested that the surrounding tissue become a periosteum according to the progress of the bone formation. In addition, the hydroxyapatite modified by a partial dissolution-precipitation technique using supersonic treatment might be improved the ability of hard tissue induction with BMP-2. Because a bony bridge formation between the new bone and the skull was not made, it was thought that the new bone on the periosteum could be removed easily and used for the bone graft.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Characterization of microstructure and bio-absorption of the hydroxyapatite ceramics modified by a partial dissolution-precipitation technique using supersonic treatment.2010

    • Author(s)
      Akazawa T, Murata M, Takahata M, Xianjun D, Abe Y, Nakamura K, Hino J, et al.
    • Journal Title

      J. Ceram. Soc. Japan 118(6)

      Pages: 535-540

    • NAID

      130000304784

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of microstructure and bio-absorption of the hydroxyapatite ceramics modified by a partial dissolution-precipitation technique using supersonic treatment2010

    • Author(s)
      Toshiyuki Akazawa, et al.
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118(6) Pages: 535-540

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 超音波部分溶解析出処理を施したHApとBMP-2複合物の頭部皮下での硬組織誘導2010

    • Author(s)
      日野純, 他
    • Organizer
      第14回生体関連セラミックス討論会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 超音波部分溶解析出処理を行ったHApとBMP-2複合物の頭部骨膜上での硬組織誘導2010

    • Author(s)
      日野純, 他
    • Organizer
      第55回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ラット頭部骨膜上での傾斜機能HAp/BMP-2の硬組織誘導と細胞増殖活性2009

    • Author(s)
      日野純, 他
    • Organizer
      第54回日本口腔外科学会総会・学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)(ゴールドリボン賞受賞)
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット頭部骨膜上での傾斜機能HAp/BMP-2の硬組織誘導と細胞増殖活性2009

    • Author(s)
      日野純, 村田勝, 田崎純一, 有末眞, 柴田考典
    • Organizer
      第54回日本口腔外科学会総会・学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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