The induction of dedifferentiation by hypoxia in OSCC cell lines.

• Project/Area Number: 21792030
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: DHASHI Masaru Showa University, 歯学部, 兼任講師 (40317524)
• Co-Investigator(Renkei-kenkyūsha): TATSUHITO Nagumo 昭和大学, 歯学部, 助教 (70555078)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 低酸素 / 癌幹細胞 / ニッチ / 口腔扁平上皮癌

Research Abstract

Recent data suggest that a rare subpopulation of cancer cells, termed cancer stem cells (CSCs), is capable of initiating, maintaining, and expanding the growth of tumor. Furthermore, these CSCs are considered a major cause of tumor recurrence after conventional therapy due to their resistance against chemo- and radio-therapeutic modalities. Thus, CSCs represent a critical therapeutic target. Recently, a number of studies have demonstrated that hypoxic tumour microenvironment controls tumour stem cells. In this study, we investigated the induction of dedifferentiation by hypoxic condition in OSCC cell lines.

Research Products

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