Analysis of new cleft palate development mechanism-about the factor of cleft palate after palatal fusion-

• Project/Area Number: 21792040
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: IMURA Hideto Aichi Gakuin University, 歯学部, 非常勤助教 (10513187)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 口蓋裂 / 口蓋突起 / 基底膜 / 器官培養 / 上皮 / 上皮索 / 発生

Research Abstract

The purpose of our study is to clarify the mechanism of cleft palate development from the interaction of the signal transduction in cells and molecules from the phenomenon of cleft palate after palatal fusion. We observed disappearance of Perlecan and IVcollagen in the basement membrane of the epithelial funiculus when both palatine processes were fusing. We observed Laminin positive cells in the basement membrane of the nasal side. And the localization of PCNA positive cells was observed in the entire of palatine processes previous palatal fusion, suggesting that cell proliferation have been active.

Research Products

• [Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion. (2010)
  • Author(s): Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T
  • Journal Title: Congenital Anomalies 50(2) Pages: 77-84
  • Peer Reviewed
• [Journal Article] Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate. (2010)
  • Author(s): Shirasu N, Ueno T, Hirata A, Kagawa T, Kanou M, Sawaki M, Wakimoto M, Ota A, Moritani N, Imura H, Matsumura T, Yamada T, Yamachika E
  • Journal Title: Acta Histochemica 112(3) Pages: 270-277
  • Peer Reviewed
• [Journal Article] Localization of the HOXC homeobox gene family during palate formation in mice. (2010)
  • Author(s): Hirata A, Imura H, Natsume N, Sugahara T
  • Journal Title: EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIALSURGER 2010. International Proceedings Pages: 415-420
  • Peer Reviewed
• [Journal Article] Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion (2010)
  • Author(s): Imura H
  • Journal Title: Congenital Anomalies Volume: 50(2) Pages: 77-84
  • Peer Reviewed
• [Presentation] 口唇口蓋裂に関する実験的研究-第124報-器官培養による口蓋突起癒合時の観察 (2010)
  • Author(s): 井村英人 平田あずみ 山田朋弘 南克浩 新美照幸 古川博雄 三島克章 藤原久美子 鈴木聡 菅原利夫 前田初彦 夏目長門
  • Organizer: 第55回日本口腔外科学会総会
  • Place of Presentation: 幕張メッセ千葉
• [Presentation] Homeobox family HOXC遺伝子は口蓋形成に関与する (2010)
  • Author(s): 平田あずみ, 井村英人, 山田朋弘, 植野高章, 三島克章, 南克浩, 夏目長門, 菅原利夫
  • Organizer: 第55回日本口腔外科学会総会
  • Place of Presentation: 幕張メッセ千葉
• [Presentation] 口唇口蓋裂患者に対する口内型骨延長装置を用いた上顎骨延長術の経験 (2009)
  • Author(s): 井村英人
  • Organizer: 第19回日本顎変形症学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-06-04