| Project/Area Number |
21792050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TAKASAKI Chihiro Hokkaido University, 大学院・歯学研究科, 助教 (60451449)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 大脳皮質 / ニューロン周囲オリゴデンドロサイト / マウス / クレアチン合成酵素 / セリン合成酵素 / グルタミン合成酵素 / 体性感覚野 |
|---|
| Research Abstract |
Perineuronal oligodendrocytes are unmyelinating oligodendrocytes attaching to large neurons in various neural regions. However, little is known about their cellular characteristics. In this study, we examined their cytochemical properties in the mouse cerebral cortex. Almost all perineuronal oligodendrocytes expressed glia-specific or glia-enriched metabolic enzymes. Interestingly, they attached more to glutamatergic principal neurons, when the cerebral cortex develops and maturates. These cytochemical properties suggest that perineuronal oligodendrocytes are so differentiated as to fulfill metabolic support to the associating principal cortical neurons.
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