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Histological analysis of a molecule involved in development of function for eating and swallowing

Research Project

Project/Area Number 21792050
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionHokkaido University

Principal Investigator

TAKASAKI Chihiro  Hokkaido University, 大学院・歯学研究科, 助教 (60451449)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords大脳皮質 / ニューロン周囲オリゴデンドロサイト / マウス / クレアチン合成酵素 / セリン合成酵素 / グルタミン合成酵素 / 体性感覚野
Research Abstract

Perineuronal oligodendrocytes are unmyelinating oligodendrocytes attaching to large neurons in various neural regions. However, little is known about their cellular characteristics. In this study, we examined their cytochemical properties in the mouse cerebral cortex. Almost all perineuronal oligodendrocytes expressed glia-specific or glia-enriched metabolic enzymes. Interestingly, they attached more to glutamatergic principal neurons, when the cerebral cortex develops and maturates. These cytochemical properties suggest that perineuronal oligodendrocytes are so differentiated as to fulfill metabolic support to the associating principal cortical neurons.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex.2010

    • Author(s)
      Takasaki C, Yamasaki M, Uchigashima M, Yanagawa Y, Konno K, Watanabe M
    • Journal Title

      European Journal of Neuroscience 32

      Pages: 1326-1336

    • NAID

      120003370661

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex.2010

    • Author(s)
      Takasaki C, Yamasaki M, Uchigashima M, Yanagawa Y, Konno K, Watanabe M.
    • Journal Title

      European Journal of Neuroscience

      Volume: 32 Pages: 1326-1336

    • NAID

      120003370661

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex.2010

    • Author(s)
      Takasaki C, Uchigashima M, Yamasaki M, Yanagawa Y, Watanabe M
    • Organizer
      7^<th> FENS Forum of European Neuroscience
    • Place of Presentation
      Amsterdam, Holland.
    • Year and Date
      2010-07-06
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳皮質体性感覚野におけるニューロン周囲オリゴデンドロサイトの化学的特性の検討2010

    • Author(s)
      高崎千尋, 大島昇平, 岡田理恵子, 八若保孝
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳皮質体性感覚野におけるニューロン周囲オリゴデンドロサイトの化学的特性の検討2010

    • Author(s)
      高崎千尋, 大島昇平, 岡田理恵子, 八若保孝
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex.2010

    • Author(s)
      Takasaki C, Uchigashima M, Yamasaki M, Yanagawa Y, Watanabe M.
    • Organizer
      7^<th> FENS Forum of European Neuroscience
    • Place of Presentation
      Amsterdam, Holland
    • Related Report
      2010 Annual Research Report
  • [Book] Neural circuit development and plasticity shaped by glutamate transporters.(eds.Tamaki N, Kuge Y)(In : Molecular Imaging for Integrated Medical Therapy and Drug Development)2009

    • Author(s)
      Miyazaki T, Takasaki C, Watanabe M
    • Publisher
      Springer Japan
    • Related Report
      2010 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(eds.Tamaki N, Kuge Y, Neural circuit development and plasticity shaped by glutamate transporters.)2009

    • Author(s)
      Miyazaki T, Takasaki C, Watanabe M
    • Publisher
      Springer Japan
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等 なし

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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