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Study for development of differentiation induction from iPS cell to dental pulp stem cell

Research Project

Project/Area Number 21792058
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

SUZUKI Hiroharu  Tohoku University, 病院, 医員 (10528087)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsiPS細胞 / 幹細胞 / 再生 / 分化誘導
Research Abstract

It doesn't relate to the development of the technology of a possible clinical application now at once, and extent from which the application of the dental pulp stem cell that uses the deciduous tooth is reported though the treatment method for the tooth germ to reproduce is developed in the odontology department regenerative medicine.
It is reported that another differentiative potential that can differentiate into neuronal cell, fat cell, and osteoblast is possessed in the cell population in which about about 1-2% exists in the dental pulp with the dental pulp stem cell. However, it is difficult to apply it to actual reproduction treatment from few of the number of cells.
Ameloblast cell line of rat origin as feeder with mouse origin iPS cell succeeded in vittro in differentiated mouse iPS cell into the ameloblast.
The inducement of the low risk ameloblast cell is enabled more efficiently by clarifying generation and the differentiation mechanism of a more detailed ameloblast by the research in the future from this result, and using new findings and it goes as base to the clinical applications of regenerative medicines of teeth.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] The role of Gja1 on salivary gland branching morphogenesis.2010

    • Author(s)
      Hiroharu Suzuki, Aya Yamada, Tsutomu Iwamoto, Takashi Nakamura, Satoshi Fukumoto
    • Organizer
      88^<th> General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺分岐におけるギャップ結合の役割解明と再生への応用2010

    • Author(s)
      鈴木宏治、山田亜矢、岩本勉、中村卓史、福本敏
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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