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Analysis of mechanism of endothelial hyperplasia caused by P.gingivalis infection

Research Project

Project/Area Number 21792066
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

NEMOTO Hirotoshi  Osaka University, 歯学部附属病院, 医員 (80527226)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords口腔細菌 / 歯周病 / P.gingivalis / 血管内皮 / 肥厚 / S100ファミリータンパク / 平滑筋 / Porphromonas ginagivalis / 平滑筋細胞 / 大動脈瘤 / 心臓弁 / S100A9 / Porphyromonas gingivalis / 増殖型 / S100カルシウム結合タンパク / 脂肪細胞
Research Abstract

Analysis of human aortic aneurysm specimens by PCR showed that the detection frequency of Porphyromonas gingivalis, a major periodontopathic bacterial species, was approximately 10%. Furthermore, histochemical analysis revealed that the intensity of S100A9 expression was significantly higher in patients harboring oral P.gingivalis than in those who did not. In addition, the proliferative type of smooth muscle cells was prominently identified in patients harboring oral P.gingivalis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (9 results)

  • [Journal Article] Characterization of aortic aneurysm of cardiovascular diseases patients with P.gingivalis occurrence.2011

    • Author(s)
      Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Hata H, Toda K, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Dis 17

      Pages: 371-378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aortic aneurysm of cardiovascular diseases patients with P.gingivalis occurrence.2011

    • Author(s)
      Nakano K, Wada K, Nomura R, Nemoto H, et al.
    • Journal Title

      Oral Diseases

      Volume: 18(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of periodontopathic bacterial species in Japanese children with developmental disabilities.2009

    • Author(s)
      Naka S, Yamana A, Nakano K, Okawa R, Fujita K, Kojima A, Nemoto H, Nomura R, Matsumoto M, Ooshima T.
    • Journal Title

      BMC Oral Health 9

      Pages: 24-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of serotype k Streptococcus mutans in Thai subjects.2009

    • Author(s)
      Lapirattanakul J, Nakano K, Nomura R, Nemoto H, Kojima A, Senawongse P, Srisatjaluk R, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 431-433

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical analyses of the gene encoding collagen-binding adhesin of Streptococcus mutans.2009

    • Author(s)
      Nomura R, Nakano K, Tanigichi N, Lapirattanakul J, Nemoto H, Gronroos L, Alaluusua S, Ooshima T.
    • Journal Title

      J Med Microbiol 58

      Pages: 469-475

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral bacteria in cardiovascular specimens.2009

    • Author(s)
      Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 64-68

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analyses of bacterial DNA in extirpated heart valves from infective endocarditis patients.2009

    • Author(s)
      Nomura R, Nakano K, Nemoto H, Mukai T, Hata H, Toda K, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 43-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral bacteria in cardiovascular specimens.2009

    • Author(s)
      Nakano K, Nemoto H, Nomura R, et al.
    • Journal Title

      Oral Microbiology and Immunology 24

      Pages: 64-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analyses of bacterial DNA in extirpated heart valves from in fective endocarditis patients.2009

    • Author(s)
      Nomura R, Nakano K, Nemoto H, et al.
    • Journal Title

      Oral Microbiology and Immunology 24

      Pages: 43-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prevalence of amoxicillin-resistant Streptococci in dental plaque of young Japanese.2011

    • Author(s)
      Nemoto H, Nakano K, Masuda K, Nomura R, Ooshima T.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2011-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Prevalence of amoxicillin-resistant Streptococci in dental plaque of young Japanese.2011

    • Author(s)
      Nemoto H, et al.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児デンタルプラーク中に存在するアモキシシリン耐性口腔細菌種の特定2010

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      平成22年度日本小児歯科学会秋季大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児デンタルプラーク中に存在するアモキシシリン耐性口腔細菌種の特定2010

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      平成22年度日本小児歯科学会秋季大会
    • Place of Presentation
      郡山市(福島県)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of amoxicillin-resistant streptococcal species in dental plaque specimens.2010

    • Author(s)
      Nemoto H, Nakano K, Nomura R, Wada K, Ooshima T.
    • Organizer
      88th IADR meeting
    • Place of Presentation
      Barcelona, Spain.
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection of amoxicillin-resistant streptococcal species in dental plaque specimens.2010

    • Author(s)
      Nemoto H, et al.
    • Organizer
      88th IADR meeting
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児プラーク中に存在するアモキシシリン耐性菌の分布に関する検討2009

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第28回日本小児歯科学会近畿地方会大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓血管系疾患患者の病変部およびデンタルプラーク検体における口腔細菌種の検出2009

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第47回日本小児歯科学会大会
    • Place of Presentation
      吹田
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓血管系疾患患者の病変部およびデンタルプラーク検体における口腔細菌種の検出2009

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第47回日本小児歯科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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