Elucidation of the healing mechanism for developing gene therapy in palatal wounds
| Project/Area Number |
21792078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YASUE Akihiro The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (80380046)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 遺伝子医薬開発 / RNAi / Smad3 / 療痕形成抑制 / SIS3 / 瘢痕形成抑制 |
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| Research Abstract |
Cleft palate patients are often subject to maxillary growth impairment and narrow dental arch after surgical closure of the defect in infancy. This is considered to be a consequence of the scar which is formed during palatal wound healing. Smad3 is one of the members concerned to TGF-b signaling pathway, and its deficient mice showed the notably accelerated wound healing in injured palates.
In this study, we investigated the effects of a specific inhibitor of Smad3 phosphorylation in wound repair, and as a result, an accelerated wound closure with down regulation of inflammatory genes was observed.
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Report
(3 results)
Research Products
(8 results)
