Role on novel protein in alveolar bone remodeling mechanism of tooth movement
| Project/Area Number |
21792083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MURAKAMI Ayako Kyushu University, 歯学研究院, 医員 (10432923)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | PRIP / 転写 / スプライシング / 歯牙移動 / 骨リモデリング / 遺伝子発現調節 / 抑制性情報伝逹 / メカニカルストレス |
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| Research Abstract |
In this study, we investigated the gene structure of PRIP-2, which exhibited an ubiquitous expression. We found several transcriptional start sites of PRIP-2 gene. This result indicates that PRIP-2 gene produces some transcripts.
To examine the role of PRIP molecule on the alveolar bone remodeling mechanism of tooth movement, we carried out Real-time PCR using tooth movement mice by orthodontic force. There was no significantly difference of the expression level of PRIP-1, PRIP-2 and each subunit of GABAA receptor in brain, between the tooth movement mice and the control.
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Report
(3 results)
Research Products
(2 results)
